(2R,αS)-α-Methyl-2-piperidineethanol

Base Information

• Chemical Name: (2R,αS)-α-Methyl-2-piperidineethanol
• CAS No.: 26171-47-1
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.229
• Mol file: 26171-47-1.mol

Synonyms:(+)-2-Allosedridine;(+)-Allosedridine;(2R,αS)-α-Methyl-2-piperidineethanol;(S)-1-[(2R)-Piperidine-2β-yl]-2-propanol

Chemical Property of (2R,αS)-α-Methyl-2-piperidineethanol

Chemical Property:

• Melting Point: 79-81 °C
• Boiling Point: 244.1±13.0 °C(Predicted)
• PKA: 15.22±0.20(Predicted)
• PSA: 32.26000
• Density: 0.927±0.06 g/cm3(Predicted)
• LogP: 1.22820

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,αS)-α-Methyl-2-piperidineethanol

There total 51 articles about (2R,αS)-α-Methyl-2-piperidineethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[2R-(2S)]-1-benzyloxycarbonyl-2-(2-hydroxypropyl)piperidine (251995-39-8) → 1-piperidin-2-yl-propan-2-ol (26171-47-1)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; for 12h;

DOI:10.1021/jo991034w

Reference yield: 98.0%

benzyl 2-(2-hydroxypropyl)piperidine-1-carboxylate (14199-09-8) → (+/-) Sedridine (501-83-7,5320-51-4,10047-06-0,26171-47-1,26619-80-7,26619-87-4,26623-96-1) + (+/-) allosedridine (501-83-7,5320-51-4,10047-06-0,26171-47-1,26619-80-7,26619-87-4,26623-96-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethyl acetate; at 30 ℃; for 4h;

DOI:10.1016/j.tetlet.2015.03.001

Reference yield: 98.0%

benzyl 2-(2-hydroxypropyl)piperidine-1-carboxylate (14199-09-8) → (+/-) Sedridine (501-83-7,5320-51-4,10047-06-0,26171-47-1,26619-80-7,26619-87-4,26623-96-1) + (+/-) allosedridine (501-83-7,5320-51-4,10047-06-0,26171-47-1,26619-80-7,26619-87-4,26623-96-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethyl acetate; at 30 ℃; for 4h;

DOI:10.1016/j.tetlet.2015.03.001

upstream raw materials:

[2R-(2R)]-1-benzyloxycarbonyl-2-(2,3-epoxypropyl)piperidine

[2R-(2S)]-1-benzyloxycarbonyl-2-(2-hydroxypropyl)piperidine

(2S,2'R)-1-[N(1')-(tert-butoxycarbonyl)piperidin-2'-yl]propan-2-ol

1-[1-(4-methylphenylsulfonyl)-piperidin-2-yl]-propan-2-ol

Downstream raw materials:

[2R-(2S)]-1-benzyloxycarbonyl-2-(2-hydroxypropyl)piperidine

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