O-DESMETHYL TRAMADOL-D6

Base Information

• Chemical Name: O-DESMETHYL TRAMADOL-D6
• CAS No.: 1109218-03-2
• Molecular Formula: C₁₅H₂₃NO₂
• Molecular Weight: 270.186
• Mol file: 1109218-03-2.mol

Synonyms:O-DESMETHYL TRAMADOL-D6;cis-(+/-)-2-[(DiMethylaMino-d6)Methyl]-1-(M-hydroxyphenyl)cyclohexanol;cis-(+/-)-3-[2-[(DiMethylaMino-d6)Methyl]-1-hydroxycyclohexyl]phenol

Chemical Property of O-DESMETHYL TRAMADOL-D6

Chemical Property:

• Melting Point: 135-141°C
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

O-DesmethylTramadol-d6 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A labelled metabolite of Tramadol, an analgesic.

Technology Process of O-DESMETHYL TRAMADOL-D6

There total 5 articles about O-DESMETHYL TRAMADOL-D6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

d6-2-(dimethylaminomethyl)cyclohexanone (873928-71-3) → C15H17(2)H6NO2 (1109218-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Mg / tetrahydrofuran

1.2: tetrahydrofuran

2.1: n-BuLi; PHPh₂ / tetrahydrofuran

With n-butyllithium; magnesium; diphenylphosphane; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2005.10.024

Reference yield:

3-methoxyphenyl bromide (2398-37-0) → C15H17(2)H6NO2 (1109218-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Mg / tetrahydrofuran

1.2: tetrahydrofuran

2.1: n-BuLi; PHPh₂ / tetrahydrofuran

With n-butyllithium; magnesium; diphenylphosphane; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2005.10.024

Reference yield:

d6-2-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexanol → C15H17(2)H6NO2 (1109218-03-2)

Guidance literature:

With n-butyllithium; diphenylphosphane; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2005.10.024

upstream raw materials:

d6-2-(dimethylaminomethyl)cyclohexanone

3-methoxyphenyl bromide