(4r,5s)-4-methyl-5-phenyl-3-piperidin-4-yl-1,3-oxazolidin-2-one hydrochloride

Base Information

• Chemical Name: (4r,5s)-4-methyl-5-phenyl-3-piperidin-4-yl-1,3-oxazolidin-2-one hydrochloride
• CAS No.: 1217459-01-2
• Molecular Formula: C₁₅H₂₀N₂O₂*ClH
• Molecular Weight: 296.797
• Mol file: 1217459-01-2.mol

Synonyms:(4r,5s)-4-methyl-5-phenyl-3-piperidin-4-yl-1,3-oxazolidin-2-one hydrochloride

Chemical Property of (4r,5s)-4-methyl-5-phenyl-3-piperidin-4-yl-1,3-oxazolidin-2-one hydrochloride

Chemical Property:

• PSA: 41.57000
• LogP: 3.38910

Purity/Quality:

99%, ^*data from raw suppliers

(4R,5S)-4-Methyl-5-phenyl-3-piperidin-4-yl-1,3-oxazolidin-2-one hydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4r,5s)-4-methyl-5-phenyl-3-piperidin-4-yl-1,3-oxazolidin-2-one hydrochloride

There total 10 articles about (4r,5s)-4-methyl-5-phenyl-3-piperidin-4-yl-1,3-oxazolidin-2-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2R)-(+)-norphedrine (37577-28-9,58550-13-3,757124-50-8) → (4R,5R)-4-Methyl-5-phenyl-3-piperidin-4-yl-oxazolidin-2-one; hydrochloride (1217459-01-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: toluene

1.2: HCl / toluene

2.1: aq. HCl / toluene

3.1: Na(OAc)3BH / 1,2-dichloro-ethane

4.1: Et₃N

5.1: HCl / ethyl acetate

With hydrogenchloride; sodium tris(acetoxy)borohydride; triethylamine; In ethyl acetate; 1,2-dichloro-ethane; toluene;

DOI:10.1016/j.bmcl.2004.12.044

Reference yield:

4-((4R,5R)-4-Methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-piperidine-1-carboxylic acid tert-butyl ester → (4R,5R)-4-Methyl-5-phenyl-3-piperidin-4-yl-oxazolidin-2-one; hydrochloride (1217459-01-2)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

DOI:10.1016/j.bmcl.2004.12.044

Reference yield:

4-((4S,5R)-4-Methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-piperidine-1-carboxylic acid tert-butyl ester → (4S,5R)-4-Methyl-5-phenyl-3-piperidin-4-yl-oxazolidin-2-one; hydrochloride (1217459-01-2)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

DOI:10.1016/j.bmcl.2004.12.044

upstream raw materials:

Norpseudoephedrine

(1S,2R)-(+)-norphedrine

N-tert-butyloxycarbonylpiperidin-4-one

4-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethylamino)-piperidine-1-carboxylic acid tert-butyl ester

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