5-broMo-2-MethanesulfonaMidobenzoic acid

Base Information

• Chemical Name: 5-broMo-2-MethanesulfonaMidobenzoic acid
• CAS No.: 1225713-29-0
• Molecular Formula: C8H8BrNO4S
• Molecular Weight: 294.126
• Hs Code.: 2935009090
• Mol file: 1225713-29-0.mol

Synonyms:5-broMo-2-MethanesulfonaMidobenzoic acid;5-BroMo-2-(MethylsulfonaMido)benzoic Acid

Chemical Property of 5-broMo-2-MethanesulfonaMidobenzoic acid

Chemical Property:

• PSA: 91.85000
• LogP: 2.67260
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2-(methylsulfonamido)benzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromo-2-(methylsulfonamido)benzoic Acid is used as a reactant in the preparation of pyrazolo[1,5-a]pyrimidines as antiviral agents.

Technology Process of 5-broMo-2-MethanesulfonaMidobenzoic acid

There total 2 articles about 5-broMo-2-MethanesulfonaMidobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 5-bromo-2-[(methylsulfonyl)amino]benzoate (452350-33-3) → 5-bromo-2-(methylsulfonamido)benzoic acid (1225713-29-0)

Guidance literature:

methyl 5-bromo-2-[(methylsulfonyl)amino]benzoate; With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

5-bromo-2-aminobenzoic acid methyl ester (52727-57-8) → 5-bromo-2-(methylsulfonamido)benzoic acid (1225713-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 20 °C

2: sodium hydroxide; water / tetrahydrofuran / 20 °C

With pyridine; water; sodium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield: 89.0%

5-bromo-2-(methylsulfonamido)benzoic acid (1225713-29-0) + C15H20ClN5O (1353628-70-2) → C23H26BrClN6O4S (1353628-72-4)

Guidance literature:

5-bromo-2-(methylsulfonamido)benzoic acid; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

C₁₅H₂₀ClN₅O; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

upstream raw materials:

methyl 5-bromo-2-[(methylsulfonyl)amino]benzoate

5-bromo-2-aminobenzoic acid methyl ester

Downstream raw materials:

C₂₃H₂₇BrN₆O₄S

C₂₃H₂₆BrClN₆O₄S

C₂₆H₃₂BrN₇O₄S

C₂₆H₃₂BrN₇O₅S

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