4-des-dimethylaminotetracycline

Base Information

• Chemical Name: 4-des-dimethylaminotetracycline
• CAS No.: 2444-65-7
• Molecular Formula: C₂₀H₁₉NO₈
• Molecular Weight: 401.373
• Mol file: 2444-65-7.mol

Synonyms:2-Naphthacenecarboxamide,1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-(6CI,7CI,8CI); 2-Naphthacenecarboxamide,1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,[4aS-(4aa,5aa,6b,12aa)]-;4-De(dimethylamino)tetracycline; CMT 1; Dedimethylamine-tetracycline;Desdimethylaminotetracycline

Chemical Property of 4-des-dimethylaminotetracycline

Chemical Property:

• Vapor Pressure: 8.14E-19mmHg at 25°C
• Boiling Point: 669.1°C at 760 mmHg
• Flash Point: 358.5°C
• PSA: 178.38000
• Density: 1.73g/cm³
• LogP: 0.78920

Purity/Quality:

99% ^*data from raw suppliers

4-DES-DIMETHYLAMINOTETRACYCLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-des-dimethylaminotetracycline

There total 6 articles about 4-des-dimethylaminotetracycline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4,4a,5,5a,6,11,12a-octahydro-2-aminocarbonyl-3,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxonaphthacene-4-trimethylammonium iodide (6602-90-0) → 4-de(dimethylamino)tetracycline (2444-65-7,110927-32-7,16639-33-1)

Guidance literature:

1,4,4a,5,5a,6,11,12a-octahydro-2-aminocarbonyl-3,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxonaphthacene-4-trimethylammonium iodide; With acetic acid; zinc; In water; at 20 ℃; for 0.25h;

With hydrogenchloride; In water; acetic acid; at 0 ℃;

Reference yield:

→ 4-de(dimethylamino)tetracycline (2444-65-7,110927-32-7,16639-33-1)

Guidance literature:

With acetic acid; zinc;

DOI:10.1021/ja01540a036 DOI:10.1021/ja01568a050

Reference yield:

→ 4-de(dimethylamino)tetracycline (2444-65-7,110927-32-7,16639-33-1)

Guidance literature:

With acetic acid; zinc;

DOI:10.1021/ja01540a036 DOI:10.1021/ja01568a050

upstream raw materials:

1,4,4a,5,5a,6,11,12a-octahydro-2-aminocarbonyl-3,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxonaphthacene-4-trimethylammonium iodide

tetracycline hydrochloride