CNX-419 hydrobroMide

Base Information

• Chemical Name: CNX-419 hydrobroMide
• CAS No.: 1446700-26-0
• Molecular Formula: C27H29BrF3N7O3
• Molecular Weight: 636.4634696
• Mol file: 1446700-26-0.mol

Synonyms:AVL-301 hydrobroMide;CNX-419 hydrobroMide;CO-1686 (hydrobroMide);CO-1686 HBr salt,Rociletinib HBr salt;AVL-301 HBr salt, CNX-419 HBr salt

Chemical Property of CNX-419 hydrobroMide

Chemical Property:

• PSA: 111.72000
• LogP: 5.96420

Purity/Quality:

97% ^*data from raw suppliers

CO-1686hydrobromide >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of CNX-419 hydrobroMide

There total 16 articles about CNX-419 hydrobroMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(N-(3-(2-(4-(4-acetylpiperazin-1-yl)-2-methoxyphenylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)phenyl)acrylamide) (1374640-70-6) → C27H28F3N7O3*2BrH (1446700-26-0)

Guidance literature:

With hydrogen bromide; In dichloromethane; at 0 - 5 ℃; for 4h; Solvent;

Reference yield:

(N-(3-(2-(4-(4-acetylpiperazin-1-yl)-2-methoxyphenylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)phenyl)acrylamide) (1374640-70-6) → C27H28F3N7O3*BrH (1446700-26-0)

Guidance literature:

With hydrogen bromide; In dichloromethane; Solvent;

Reference yield:

N-[3-[[2-chloro-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide (1374507-25-1) → C27H28F3N7O3*BrH (1446700-26-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,4-dioxane / 50 °C

2: sodium carbonate / dichloromethane; water / 0.58 h / 0 - 20 °C / pH > 8

3: hydrogen bromide / dichloromethane

With hydrogen bromide; sodium carbonate; In 1,4-dioxane; dichloromethane; water;

upstream raw materials:

N-[3-[[2-chloro-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide

(N-(3-(2-(4-(4-acetylpiperazin-1-yl)-2-methoxyphenylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)phenyl)acrylamide)

2,4-dichloro-5-trifluoromethylpyrimidine

(3-aminophenyl)carbamic acid tert-butyl ester