7-Phenylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Base Information

• Chemical Name: 7-Phenylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid
• CAS No.: 874773-92-9
• Molecular Formula: C₁₃H₉N₃O₂
• Molecular Weight: 239.233
• Hs Code.: 2933990090
• European Community (EC) Number: 899-229-4
• ChEMBL ID: CHEMBL1309413
• Mol file: 874773-92-9.mol

Synonyms:874773-92-9;7-phenylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid;7-Phenyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid;MLS001208441;CHEMBL1309413;HMS1700H07;HMS2814G17;HMS3437O17;ZJB77392;MFCD03407413;AKOS000207558;SMR000504165;CS-0139383;EN300-39113;C77653;7-phenylpyrazolo[1,5-a]pyrimidine-3-carboxylicacid;BRD-K67009981-001-07-4;Z321074690

Chemical Property of 7-Phenylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Chemical Property:

• PSA: 67.49000
• LogP: 2.09450
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 239.069476538
• Heavy Atom Count: 18
• Complexity: 317

Purity/Quality:

98%min ^*data from raw suppliers

7-Phenyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=NC3=C(C=NN23)C(=O)O

Technology Process of 7-Phenylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid

There total 5 articles about 7-Phenylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 7-phenylpyrazolo[1,5-a]pyrimidine-3-carboxylate → 7-phenylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid (874773-92-9)

Guidance literature:

methyl 7-phenylpyrazolo[1,5-a]pyrimidine-3-carboxylate; With water; sodium hydroxide; In methanol; at 50 ℃; for 1h;

With hydrogenchloride; In water; pH=Ca. 1;

DOI:10.1016/j.tet.2014.09.020

Reference yield:

3-(methoxycarbonyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylic acid → 7-phenylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid (874773-92-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: quinoline; copper / 0.75 h / 180 °C

2.1: trichlorophosphate; triethylamine / 3 h / Reflux

3.1: caesium carbonate; bis(η3-allyl-μ-chloropalladium(II)); tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 24 h / 95 °C

4.1: water; sodium hydroxide / methanol / 1 h / 50 °C

4.2: pH Ca_. 1

With quinoline; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(η3-allyl-μ-chloropalladium(II)); water; copper; caesium carbonate; triethylamine; sodium hydroxide; trichlorophosphate; In methanol; N,N-dimethyl-formamide; 3.1: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.tet.2014.09.020

Reference yield:

methyl 7-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate → 7-phenylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid (874773-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: caesium carbonate; bis(η3-allyl-μ-chloropalladium(II)); tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 24 h / 95 °C

2.1: water; sodium hydroxide / methanol / 1 h / 50 °C

2.2: pH Ca_. 1

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(η3-allyl-μ-chloropalladium(II)); water; caesium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; 1.1: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.tet.2014.09.020