N-(Hydroxyacetyl)-2-O-Methyl-α-neuraMinic Acid

Base Information

Chemical Name:N-(Hydroxyacetyl)-2-O-Methyl-α-neuraMinic Acid
CAS No.:14206-42-9
Molecular Formula:C12H21NO10
Molecular Weight:339.29584
Hs Code.:
Mol file:14206-42-9.mol

Synonyms:N-(Hydroxyacetyl)-2-O-Methyl-α-neuraMinic Acid

Suppliers and Price of N-(Hydroxyacetyl)-2-O-Methyl-α-neuraMinic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-(Hydroxyacetyl)-2-O-methyl-α-neuraminicAcid
10mg
$ 1320.00

Total 4 raw suppliers

Chemical Property of N-(Hydroxyacetyl)-2-O-Methyl-α-neuraMinic Acid

Chemical Property:

PSA：186.01000
LogP:-3.85440

Purity/Quality:

95% ^*data from raw suppliers

N-(Hydroxyacetyl)-2-O-methyl-α-neuraminicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-(Hydroxyacetyl)-2-O-methyl-α-neuraminic Acid is used as a scaffold in study of the binding sites, the siglec (sialic acid binding Ig-lectins) transmembrane receptors, within sialylated glycoconjugates that modulate cellular interactions and signalling events within the immune and nervous systems. Potential for inhibitor design.

Technology Process of N-(Hydroxyacetyl)-2-O-Methyl-α-neuraMinic Acid

There total 8 articles about N-(Hydroxyacetyl)-2-O-Methyl-α-neuraMinic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1454818-67-7
ammonium (methyl 5-amino-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosid)onate

: 13831-31-7
Acetoxyacetyl chloride

: 14206-42-9
methyl 3,5-dideoxy-5-(2-hydroxyacetamido)-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid

Guidance literature:: ammonium (methyl 5-amino-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosid)onate; Acetoxyacetyl chloride; With triethylamine; In 1,4-dioxane; water; at 0 - 40 ℃; for 2h; Microwave irradiation; Sealed tube;

With methanol; sodium hydroxide; In water; at 0 - 20 ℃; for 1h; Microwave irradiation; Sealed tube;

In water; Microwave irradiation; Sealed tube;
DOI:10.1016/j.tetlet.2013.07.107

Reference yield: 73.0%

: C₂₃H₃₃NO₁₅

: 14206-42-9
methyl 3,5-dideoxy-5-(2-hydroxyacetamido)-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 17h; Inert atmosphere;
DOI:10.1021/acs.orglett.8b01288

Reference yield:

: 6813-81-6,14120-72-0,19342-33-7,21646-00-4,82349-00-6,99395-98-9,99395-99-0,99396-00-6,102734-10-1,489-46-3,140671-47-2,140850-42-6,140850-43-7,140850-44-8,145375-13-9
N-acetyl neuraminic acid

: 14206-42-9
methyl 3,5-dideoxy-5-(2-hydroxyacetamido)-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 100 °C / Sealed tube; Inert atmosphere

2.1: sodium methylate; triethylamine / methanol / 5 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: sodium hydroxide / methanol / 17 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium methylate; triethylamine; sodium hydroxide; In methanol; water;
DOI:10.1021/acs.orglett.8b01288