5-Fluoro-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:5-Fluoro-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
CAS No.:69123-95-1
Molecular Formula:C₉H₁₀F₂N₂O₅
Molecular Weight:264.186
Hs Code.:
UNII:Q9Z0U8F4YH
ChEMBL ID:CHEMBL3228490
Nikkaji Number:J1.124.905A
Mol file:69123-95-1.mol

Synonyms:1-(2'-deoxy-2'-fluoro-beta--arabinofuranosyl)-5-fluorouracil;2',5-difluoro-1-arabinosyluracil;2',5-difluoro-2'-deoxy-1-arabinosyluracil;2'-F-ara-FU;FF-ara-Ura

Suppliers and Price of 5-Fluoro-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
5-Fluoro-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 97%
1g
$ 1140.00

Chemenu
5-fluoro-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 97%
1g
$ 1066.00

Total 15 raw suppliers

Chemical Property of 5-Fluoro-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Chemical Property:

PSA：37.30000
Density:1.69 g/cm³
LogP:3.55960
XLogP3:-1.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:264.05577775
Heavy Atom Count:18
Complexity:416

Purity/Quality:

99% ^*data from raw suppliers

5-Fluoro-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=O)NC(=O)N1C2C(C(C(O2)CO)O)F)F
Isomeric SMILES:C1=C(C(=O)NC(=O)N1[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)F)F

Technology Process of 5-Fluoro-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

There total 3 articles about 5-Fluoro-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-((2R,3S,4R,5R)-4-Benzyloxy-5-benzyloxymethyl-3-fluoro-tetrahydro-furan-2-yl)-5-fluoro-1H-pyrimidine-2,4-dione

: 69123-95-1
2',5-difluoro-1-arabinosyluracil (FFara-Ura)

Guidance literature:: With sodium methylate; In methanol; Heating;
DOI:10.1002/jlcr.637

Reference yield:

: 2-fluoro-2-deoxy-3,5-di-O-benzoyl-α-D-1-bromo-arabinofuranose

: 69123-95-1
2',5-difluoro-1-arabinosyluracil (FFara-Ura)

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / 1 h / 100 °C

2: sodium methoxide / methanol / Heating

With sodium methylate; In methanol; 1,2-dichloro-ethane;
DOI:10.1002/jlcr.637