N-tert-Butyloxycarbonyl Glutathione DiMethyl Diester Disulfide DiMer

Base Information

• Chemical Name: N-tert-Butyloxycarbonyl Glutathione DiMethyl Diester Disulfide DiMer
• CAS No.: 566172-19-8
• Molecular Formula: C34H56N6O16S2
• Molecular Weight: 868.97
• Mol file: 566172-19-8.mol

Synonyms:N-tert-Butyloxycarbonyl Glutathione DiMethyl Diester Disulfide DiMer;N-[(1,1-DiMethylethoxy)carbonyl]-L-γ-glutaMyl-L-cysteinyl-glycine 1,3-DiMethyl Ester (2→2')-Disulfide DiMer

Chemical Property of N-tert-Butyloxycarbonyl Glutathione DiMethyl Diester Disulfide DiMer

Chemical Property:

• PSA: 348.86000
• LogP: 1.95420
• Solubility.: Chloroform, Dichloromethane, Methanol

Purity/Quality:

99% ^*data from raw suppliers

N-tert-Butyloxycarbonyl glutathione dimethyl diester disulfide dimer ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-tert-Butyloxycarbonyl Glutathione DiMethyl Diester Disulfide DiMer is used in the preparation of Glutathione (G597951) and its derivatives.

Technology Process of N-tert-Butyloxycarbonyl Glutathione DiMethyl Diester Disulfide DiMer

There total 3 articles about N-tert-Butyloxycarbonyl Glutathione DiMethyl Diester Disulfide DiMer which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + di[2H3-methylo]glutathione (97451-41-7) → bis-(N'-Boc)-L-glutathione disulfide tetramethyl ester (566172-19-8)

Guidance literature:

di[²H₃-methylo]glutathione; With iodine; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

di-tert-butyl dicarbonate; In N,N-dimethyl-formamide; for 1h;

DOI:10.1021/ja907150m

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + L-glutathione disulfide tetramethyl ester dihydrochloride (146963-33-9) → bis-(N'-Boc)-L-glutathione disulfide tetramethyl ester (566172-19-8)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 23 ℃; for 29h;

DOI:10.1016/j.bmc.2006.10.022

Reference yield:

Oxidized glutathione (27025-41-8,121-24-4,87140-29-2) → bis-(N'-Boc)-L-glutathione disulfide tetramethyl ester (566172-19-8)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / 80 h / 0 °C

2: NaHCO₃ / tetrahydrofuran; H₂O / 29 h / 23 °C

With hydrogenchloride; sodium hydrogencarbonate; In tetrahydrofuran; water;

DOI:10.1016/j.bmc.2006.10.022

upstream raw materials:

di-tert-butyl dicarbonate

L-glutathione disulfide tetramethyl ester dihydrochloride

Oxidized glutathione

di[²H₃-methylo]glutathione

Downstream raw materials:

methyl N²-(tert-butoxycarbonyl)-N⁵-((R)-3-mercapto-1-((2-methoxy-2-oxoethyl)amino)-1-oxopropan-2-yl)-L-glutaminate

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