(5-(Trifluoromethyl)pyridin-2-yl)methanamine hydrochloride

Base Information

• Chemical Name: (5-(Trifluoromethyl)pyridin-2-yl)methanamine hydrochloride
• CAS No.: 871826-12-9
• Molecular Formula: C7H8ClF3N2
• Molecular Weight: 212.602
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID50590042
• Mol file: 871826-12-9.mol

Synonyms:871826-12-9;(5-(Trifluoromethyl)pyridin-2-yl)methanamine hydrochloride;[5-(trifluoromethyl)pyridin-2-yl]methanamine hydrochloride;2-(Aminomethyl)-5-(trifluoromethyl)pyridine hydrochloride;[5-(trifluoromethyl)pyridin-2-yl]methanamine;hydrochloride;MFCD05863878;2-(Aminomethyl)-5-(trifluoromethyl)pyridine HCl;C-(5-Trifluoromethyl-pyridin-2-yl)methylamine, HCl;C-(5-TRIFLUOROMETHYL-PYRIDIN-2-YL)METHYLAMINE HYDROCHLORIDE;SCHEMBL3902582;(5-(TRIFLUOROMETHYL)PYRIDIN-2-YL)METHANAMINE HCL;(5-(Trifluoromethyl)pyridin-2-yl)methanaminehydrochloride;DTXSID50590042;HVXHWBMLTSDYGK-UHFFFAOYSA-N;AMY34496;AR2105;AKOS016002466;PS-7981;SB11099;SY077890;DB-088237;CS-0042147;2-Aminomethyl-5-(trifluoromethyl) pyridine HCl;EN300-7365872;A862740;J-010131;J-501521;[5-(Trifluoromethyl)-2-pyridyl]methanamine hydrochloride;Z3235024347;C-(5-TRIFLUOROMETHYL-PYRIDIN-2-YL)METHYLAMINE HCL;C-(5-Trifluoromethyl-pyridin-2-yl)-methylamine hydrochloride;C-(5-Trifluoromethyl-pyridin-2-yl)-methylamine;1-[5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]METHANAMINE HYDROCHLORIDE;1-[5-(Trifluoromethyl)pyridin-2-yl]methanamine--hydrogen chloride (1/1);c-(5-trifluoromethyl-pyridin-2-yl)methylamine hydrochloride, AldrichCPR

Chemical Property of (5-(Trifluoromethyl)pyridin-2-yl)methanamine hydrochloride

Chemical Property:

• PSA: 38.91000
• LogP: 3.06140
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 212.0328104
• Heavy Atom Count: 13
• Complexity: 146

Purity/Quality:

97% ^*data from raw suppliers

(5-(Trifluoromethyl)pyridin-2-yl)methanaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=NC=C1C(F)(F)F)CN.Cl

Technology Process of (5-(Trifluoromethyl)pyridin-2-yl)methanamine hydrochloride

There total 1 articles about (5-(Trifluoromethyl)pyridin-2-yl)methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

3-chloro-2-cyano-5-(trifluoromethyl)pyridine (80194-70-3) → 1-[5-(trifluoromethyl)pyridin-2-yl]methanamine hydrochloride (871826-12-9,1350637-24-9)

Guidance literature:

With hydrogenchloride; 5% rhodium-on-charcoal; hydrogen; In methanol; water; at 100 ℃; for 10h; under 7500.75 - 11251.1 Torr; Pressure; Catalytic behavior; Autoclave;

Reference yield: 75.0%

2-amino-3,4-difluoronitro-benzene (211693-73-1) + 1-[5-(trifluoromethyl)pyridin-2-yl]methanamine hydrochloride (871826-12-9,1350637-24-9) → 2-fluoro-4-nitro-N1-((5-(trifluoromethyl)pyridin-2-yl)methyl)benzene-1,3-diamine

Guidance literature:

1-[5-(trifluoromethyl)pyridin-2-yl]methanamine hydrochloride; With water; sodium hydroxide;

2-amino-3,4-difluoronitro-benzene; With iodine; triethylamine; In dimethyl sulfoxide; at 120 ℃; for 30h; Inert atmosphere;

Reference yield: 53.0%

1-[5-(trifluoromethyl)pyridin-2-yl]methanamine hydrochloride (871826-12-9,1350637-24-9) + 2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]-5-carboxylic acid 1',1'-dioxide (1448039-26-6) → 2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-N-{[(5-trifluoromethyl)pyridin-2-yl]methyl}-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]-5-carboxamide 1',1'-dioxide (1448040-74-1)

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/acs.jmedchem.0c01076

upstream raw materials:

3-chloro-2-cyano-5-(trifluoromethyl)pyridine

Downstream raw materials:

3-oxo-N-(4-(trifluoromethoxy)benzyl)-2-((5-(trifluoromethyl)pyridin-2-yl)methyl)isoindoline-1-carboxamide

2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-N-{[(5-trifluoromethyl)pyridin-2-yl]methyl}-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]-5-carboxamide 1',1'-dioxide

(5-(trifluoromethyl)pyridin-2-yl)methanamine