1H-Pyrrolizine-1,2,6-triol, hexahydro-, (1S,2R,6R,7aS)- (9CI)

Base Information

• Chemical Name: 1H-Pyrrolizine-1,2,6-triol, hexahydro-, (1S,2R,6R,7aS)- (9CI)
• CAS No.: 404346-77-6
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.185
• Mol file: 404346-77-6.mol

Synonyms:1H-Pyrrolizine-1,2,6-triol, hexahydro-, (1S,2R,6R,7aS)- (9CI)

Chemical Property of 1H-Pyrrolizine-1,2,6-triol, hexahydro-, (1S,2R,6R,7aS)- (9CI)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrolizine-1,2,6-triol, hexahydro-, (1S,2R,6R,7aS)- (9CI)

There total 23 articles about 1H-Pyrrolizine-1,2,6-triol, hexahydro-, (1S,2R,6R,7aS)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(3aS,7S,8aR,8bR)-2,2-dimethylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizin-7-ol (1060658-05-0) → (1R,2S,6S,7aR)-hexahydro-1H-pyrrolizine-1,2,6-triol (1060658-07-2,404346-77-6)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2008.06.093

Reference yield: 85.0%

(3aS,7R,8aR,8bR)-2,2-dimethylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizin-7-ol (1060658-04-9) → (1R,2S,6R,7aR)-hexahydro-1H-pyrrolizine-1,2,6-triol (1060658-06-1,404346-77-6)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2008.06.093

Reference yield: 80.0%

(1R,2S,6R,7aR)-1,2,6-trihydroxyhexahydro-1H-pyrrolizin-3-one (1604804-42-3) → (1R,2R,6R,7aR)-1,2,6-trihydroxyhexahydro-1H-pyrrolizine-1,2,6-triol (404346-77-6)

Guidance literature:

With aluminium hydride; In tetrahydrofuran; for 3h; Reflux;

DOI:10.1016/j.tet.2013.10.050

upstream raw materials:

tert-butyl (2S,4S)-4-hydroxy-2-[(1R)-1-hydroxy-3-methoxy-2-methylidene-3-oxopropyl]pyrrolidine-1-carboxylate

tert-butyl (2S,4S)-2-formyl-4-hydroxypyrrolidine-1-carboxylate

(2S,4R)-1-tert-butyl 2-ethyl 4-hydroxypyrrolidine-1,2-dicarboxylate

(1R,6S,7aS)-1,6-dihydroxy-2-methylidene-hexahydro-1Hpyrrolizin-3-one