((2R,3R,4R,5R)-3-(benzoyloxy)-4-chloro-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-4-Methyltetrahydrofuran-2-yl)Methyl benzoate

Base Information

• Chemical Name: ((2R,3R,4R,5R)-3-(benzoyloxy)-4-chloro-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-4-Methyltetrahydrofuran-2-yl)Methyl benzoate
• CAS No.: 1496551-71-3
• Molecular Formula: C24H21ClN2O7
• Molecular Weight: 484.893
• Mol file: 1496551-71-3.mol

Synonyms:((2R,3R,4R,5R)-3-(benzoyloxy)-4-chloro-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-4-Methyltetrahydrofuran-2-yl)Methyl benzoate

Chemical Property of ((2R,3R,4R,5R)-3-(benzoyloxy)-4-chloro-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-4-Methyltetrahydrofuran-2-yl)Methyl benzoate

Chemical Property:

• PKA: 9.39±0.10(Predicted)
• PSA: 116.69000
• Density: 1.44±0.1 g/cm3(Predicted)
• LogP: 2.51410

Purity/Quality:

NLT 98% ^*data from raw suppliers

((2R,3R,4R,5R)-3-(benzoyloxy)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methyltetrahydrofuran-2-yl)methylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((2R,3R,4R,5R)-3-(benzoyloxy)-4-chloro-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-4-Methyltetrahydrofuran-2-yl)Methyl benzoate

There total 6 articles about ((2R,3R,4R,5R)-3-(benzoyloxy)-4-chloro-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-4-Methyltetrahydrofuran-2-yl)Methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2'-deoxy-2'-chloro-2'-C-methyl-3',5'-di-O-benzoyl-N4-benzoylcytidine (1496551-70-2) → C24H21ClN2O7 (1496551-71-3)

Guidance literature:

With water; acetic acid; at 110 ℃;

DOI:10.1016/j.bmcl.2017.08.029

Reference yield: 88.9%

C31H28ClN3O7 → C24H21ClN2O7 (1496551-71-3)

Guidance literature:

With acetic acid; at 110 ℃; for 12h;

Reference yield:

C20H18BrClO5 → C24H21ClN2O7 (1496551-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,1,1,3,3,3-hexamethyl-disilazane; tin(IV) chloride / chlorobenzene / 70 °C

2: acetic acid; water / 110 °C

With water; tin(IV) chloride; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In chlorobenzene;

DOI:10.1016/j.bmcl.2017.08.029

upstream raw materials:

2'-deoxy-2'-chloro-2'-C-methyl-3',5'-di-O-benzoyl-N⁴-benzoylcytidine

Downstream raw materials:

1-((2R,3R,4R,5R)-3-chloro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

C₁₇H₁₅ClFIN₂O₅

C₁₇H₁₆ClFN₂O₆

C₂₂H₂₈ClFN₃O₉P

Refernces

• 1、 -. "Deuterated HCV NS5b inhibitor nucleotide derivative and application thereof". Paragraph 0037-0039. . Retrieved 2017/07/19.
• 2、 -. "SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF". Paragraph 0690-0691. . Retrieved 2016/03/11.