1-(3,4-DiMethoxycinnaMoyl)piperidine

Base Information

• Chemical Name: 1-(3,4-DiMethoxycinnaMoyl)piperidine
• CAS No.: 128261-84-7
• Molecular Formula: C₁₆H₂₁NO₃
• Molecular Weight: 275.348
• Mol file: 128261-84-7.mol

Synonyms:1-(3,4-DiMethoxycinnaMoyl)piperidine;(2E)-3-(3,4-Dimethoxyphenyl)-1-(1-piperidinyl)-2-propen-1-one

Chemical Property of 1-(3,4-DiMethoxycinnaMoyl)piperidine

Chemical Property:

• PSA: 38.77000
• LogP: 2.66740

Purity/Quality:

98% ^*data from raw suppliers

2-(4-fluorobenzoyl)-1-benzofuran-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3,4-DiMethoxycinnaMoyl)piperidine

There total 6 articles about 1-(3,4-DiMethoxycinnaMoyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

piperidine (110-89-4) + 3,4-dimethoxy-trans-cinnamic acid (14737-89-4) → (E)-3-(3,4-Dimethoxy-phenyl)-1-piperidin-1-yl-propenone (128261-84-7)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 6h; Ambient temperature;

Reference yield: 42.3%

piperidine (110-89-4) + 3,4-dimethoxy-trans-cinnamic acid (14737-89-4) → (E)-3-(benzoyl 3,4-dimethoxy)-1-(piperidin-1-yl)prop-2-en-1-one (128261-84-7)

Guidance literature:

3,4-dimethoxy-trans-cinnamic acid; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

piperidine; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.bmc.2004.01.036

Reference yield:

piperidine (110-89-4) + (E)-3,4-dimethoxycinnamic chloride (39856-08-1,141236-46-6) → (E)-3-(benzoyl 3,4-dimethoxy)-1-(piperidin-1-yl)prop-2-en-1-one (128261-84-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 8h;

DOI:10.3390/molecules26082293

upstream raw materials:

piperidine

3,4-dimethoxy-trans-cinnamic acid

(E)-3,4-dimethoxycinnamic chloride

3,4-dimethoxy-benzaldehyde