2-chloro-5-Methyl-3H-pyrrolo[3,2-d]pyriMidin-4(5H)-one

Base Information

• Chemical Name: 2-chloro-5-Methyl-3H-pyrrolo[3,2-d]pyriMidin-4(5H)-one
• CAS No.: 129872-84-0
• Molecular Formula: C₇H₆ClN₃O
• Molecular Weight: 183.597
• Hs Code.: 2933990090
• Mol file: 129872-84-0.mol

Synonyms:2-chloro-5-Methyl-3H-pyrrolo[3,2-d]pyriMidin-4(5H)-one;2-Chloro-5-Methyl-5H-pyrrolo[3,2-d]pyriMidin-4(3H)-one;2-Chloro-3,5-dihydro-5-Methyl-4H-pyrrolo[3,2-d]pyriMidin-4-one;2-chloro-5-methyl-1H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one

Chemical Property of 2-chloro-5-Methyl-3H-pyrrolo[3,2-d]pyriMidin-4(5H)-one

Chemical Property:

• PSA: 50.94000
• LogP: 1.32730
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2-Chloro-5-methyl-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-5-Methyl-3H-pyrrolo[3,2-d]pyriMidin-4(5H)-one

There total 2 articles about 2-chloro-5-Methyl-3H-pyrrolo[3,2-d]pyriMidin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,4-dichloro-5-methyl-5H-pyrrolo<3,2-d>pyrimidine (129872-81-7) → 2-chloro-5-methyl-5H-pyrrolo<3,2-d>pyrimidin-4(3H)-one (129872-84-0)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; for 1h; Heating;

DOI:10.1021/jm00172a011

Reference yield:

2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine (63200-54-4) → 2-chloro-5-methyl-5H-pyrrolo<3,2-d>pyrimidin-4(3H)-one (129872-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) MeCN, RT, 30 min, 2.) a) 0-5 deg C, 15 min, b) RT, overnight

2: 94 percent / NaOH / dioxane / 1 h / Heating

With sodium hydroxide; sodium hydride; In 1,4-dioxane;

DOI:10.1021/jm00172a011

Reference yield:

2-chloro-5-methyl-5H-pyrrolo<3,2-d>pyrimidin-4(3H)-one (129872-84-0) → C33H27ClN4O8

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / NH₃ / methanol / 12 h / 160 °C

2: 47 percent / SnCl₄ / nitromethane / 3 h / 60 °C

3: 93 percent / sulfuryl chloride / CH₂Cl₂ / 1.) 0-5 deg C, 30 min, 2.) RT, 6 h

With sulfuryl dichloride; ammonia; tin(IV) chloride; In methanol; nitromethane; dichloromethane;

DOI:10.1021/jm00172a011

upstream raw materials:

2,4-dichloro-5-methyl-5H-pyrrolo<3,2-d>pyrimidine

2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine

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