6-(5-(BOC-AMINO)-2-METHYLPHENYLAMINO)-3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLINE

Base Information

Chemical Name:6-(5-(BOC-AMINO)-2-METHYLPHENYLAMINO)-3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLINE
CAS No.:878745-39-2
Molecular Formula:C21H24N4O3
Molecular Weight:380.447
Hs Code.:

Synonyms:6-(5-(BOC-AMINO)-2-METHYLPHENYLAMINO)-3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLINE

Suppliers and Price of 6-(5-(BOC-AMINO)-2-METHYLPHENYLAMINO)-3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)carbamate 97%
250mg
$ 594.00

Crysdot
tert-Butyl(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)carbamate 97%
1g
$ 1488.00

Chemenu
tert-Butyl(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)carbamate 97%
1g
$ 1403.00

Alichem
6-(5-(Boc-amino)-2-methylphenylamino)-3-methyl-4-oxo-3,4-dihydroquinazoline
1g
$ 1363.50

Alichem
6-(5-(Boc-amino)-2-methylphenylamino)-3-methyl-4-oxo-3,4-dihydroquinazoline
250mg
$ 540.00

Total 0 raw suppliers

Chemical Property of 6-(5-(BOC-AMINO)-2-METHYLPHENYLAMINO)-3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLINE

Chemical Property:

PSA：85.25000
LogP:4.47850

Purity/Quality:: tert-Butyl(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-(5-(BOC-AMINO)-2-METHYLPHENYLAMINO)-3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLINE

There total 7 articles about 6-(5-(BOC-AMINO)-2-METHYLPHENYLAMINO)-3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 660838-05-1
t-butyl 3-amino-4-methylphenylcarbamate

: 16064-09-8
6-chloro-3-methylquinazolin-4(3H)-one

: 878745-39-2
tert-butyl 4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenylcarbamate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dibutyl butylphosphonate; sodium t-butanolate; for 8h;
DOI:10.1016/j.bmc.2009.10.055

Reference yield: 58.0%

: 660838-05-1
t-butyl 3-amino-4-methylphenylcarbamate

: 57573-59-8
6-bromo-3-N-methylquinazoline-4(3H)-one

: 878745-39-2
tert-butyl 4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenylcarbamate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 80 ℃; for 12h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 878745-39-2
tert-butyl 4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 65 °C / Reflux

2: 5%-palladium/activated carbon; hydrogen / ethanol / 15 h / 2585.81 Torr

3: sodium methylate; johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 8 h / Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5%-palladium/activated carbon; hydrogen; sodium methylate; johnphos; In tetrahydrofuran; ethanol; toluene;