N-[3-Fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Base Information

• Chemical Name: N-[3-Fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide
• CAS No.: 913376-84-8
• Molecular Formula: C₃₁H₂₉FN₄O₅
• Molecular Weight: 556.593
• ChEMBL ID: CHEMBL445799
• DSSTox Substance ID: DTXSID201101055
• Pharos Ligand ID: NSYQWDRA2246
• Wikidata: Q27163246
• Wikipedia: AMG-1
• Mol file: 913376-84-8.mol

Synonyms:6-(5-hydroxy-2-pyridylmethylamino)-9-beta-ribofuranosylpurine;AMG 1;AMG-1

Chemical Property of N-[3-Fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Chemical Property:

• PSA: 107.61000
• LogP: 5.53180
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 8
• Exact Mass: 556.21219820
• Heavy Atom Count: 41
• Complexity: 986

Purity/Quality:

97% ^*data from raw suppliers

AMG-1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC)F
• Uses: AMG-1 is a potent inhibitor of human c-Met and RON.

Technology Process of N-[3-Fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

There total 2 articles about N-[3-Fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-fluoro-4-(7-methoxyquinolin-4-yloxy)benzenamine (913376-57-5) + 1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (913376-56-4) → N-(3-fluoro-4-(7-methoxyquinolin-4-yloxy)phenyl)-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (913376-84-8)

Guidance literature:

3-fluoro-4-(7-methoxyquinolin-4-yloxy)benzenamine; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 37 ℃; for 0.25h;

1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid; In N,N-dimethyl-formamide; at 37 ℃; for 18h;

DOI:10.1021/jm800401t

Reference yield:

→ N-(3-fluoro-4-(7-methoxyquinolin-4-yloxy)phenyl)-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (913376-84-8)

Guidance literature:

upstream raw materials:

3-fluoro-4-(7-methoxyquinolin-4-yloxy)benzenamine

1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

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