4-(2-(Methylthio)pyriMidin-4-yl)-1H-pyrazol-5-aMine

Base Information

• Chemical Name: 4-(2-(Methylthio)pyriMidin-4-yl)-1H-pyrazol-5-aMine
• CAS No.: 956722-10-4
• Molecular Formula: C₈H₉N₅S
• Molecular Weight: 207.259
• Hs Code.: 2933990090
• Mol file: 956722-10-4.mol

Synonyms:4-(2-(Methylthio)pyriMidin-4-yl)-1H-pyrazol-5-aMine;4-(2-(Methylthio)pyriMidin-4-yl)-1H-pyrazol-3-aMine;4-(2-Methylsulfanyl-pyriMidin-4-yl)-2H-pyrazol-3-ylaMine

Chemical Property of 4-(2-(Methylthio)pyriMidin-4-yl)-1H-pyrazol-5-aMine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 507.324°C at 760 mmHg
• Flash Point: 260.62°C
• PSA: 106.51000
• Density: 1.458g/cm³
• LogP: 1.10090

Purity/Quality:

97% ^*data from raw suppliers

4-(2-(Methylthio)pyrimidin-4-yl)-1H-pyrazol-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-(Methylthio)pyriMidin-4-yl)-1H-pyrazol-5-aMine

There total 3 articles about 4-(2-(Methylthio)pyriMidin-4-yl)-1H-pyrazol-5-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.8%

2-[2-(methylsulfanyl)pyrimidin-4-yl]-3-oxopropanenitrile (1111637-81-0) → 4-(2-(methylthio)pyrimidin-4-yl)-1H-pyrazol-5-amine (956722-10-4)

Guidance literature:

With hydrogenchloride; hydrazine; In ethanol; water; for 5h; Heating / reflux;

Reference yield:

3-(dimethylamino)-2-(2-(methylthio)pyrimidin-4-yl)acrylonitrile (1269440-83-6) → 4-(2-(methylthio)pyrimidin-4-yl)-1H-pyrazol-3-amine (956722-10-4)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 16h;

Reference yield:

(2-(methylthio)pyrimidin-4-yl)acetonitrile (897648-40-7) → 4-(2-(methylthio)pyrimidin-4-yl)-1H-pyrazol-3-amine (956722-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 16 h / 100 °C

2: hydrazine hydrate / ethanol / 16 h / 80 °C

With hydrazine hydrate; In ethanol;

upstream raw materials:

2-[2-(methylsulfanyl)pyrimidin-4-yl]-3-oxopropanenitrile

(2-(methylthio)pyrimidin-4-yl)acetonitrile

3-(dimethylamino)-2-(2-(methylthio)pyrimidin-4-yl)acrylonitrile

Downstream raw materials:

4-(5-iodo-1H-pyrazol-4-yl)-2-(methylthio)pyrimidine

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