(2-Benzylisoindolin-5-yl)methanol

Base Information

• Chemical Name: (2-Benzylisoindolin-5-yl)methanol
• CAS No.: 127169-16-8
• Molecular Formula: C16H17NO
• Molecular Weight: 239.317
• DSSTox Substance ID: DTXSID90600396
• Wikidata: Q82496451
• Mol file: 127169-16-8.mol

Synonyms:(2-Benzylisoindolin-5-yl)methanol;127169-16-8;(2-BENZYL-1,3-DIHYDROISOINDOL-5-YL)METHANOL;SCHEMBL1206388;DTXSID90600396;OJYMOHXXGCNJGW-UHFFFAOYSA-N;CFA16916;AB6225;SB65081;DA-13033;CS-0357135;(2-benzyl-2,3-dihydro-1H-isoindol-5-yl)-methanol;(2-Benzyl-2,3-dihydro-1H-isoindol-5-yl)methanol

Chemical Property of (2-Benzylisoindolin-5-yl)methanol

Chemical Property:

• Boiling Point: 376.3±37.0 °C(Predicted)
• PKA: 14.44±0.10(Predicted)
• PSA: 23.47000
• Density: 1.186±0.06 g/cm3(Predicted)
• LogP: 2.63260
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 239.131014166
• Heavy Atom Count: 18
• Complexity: 262

Purity/Quality:

98%min ^*data from raw suppliers

(2-benzylisoindolin-5-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=C(CN1CC3=CC=CC=C3)C=C(C=C2)CO

Technology Process of (2-Benzylisoindolin-5-yl)methanol

There total 3 articles about (2-Benzylisoindolin-5-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 2,3-dihydro-2-(phenylmethyl)-1H-isoindole-5-carboxylate (127168-94-9) → (2-benzyl-2,3-dihydro-1H-isoindol-5-yl)1-methanol (127169-16-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2.25h;

Reference yield:

methyl 3,4-dimethylbenzoate (38404-42-1) → (2-benzyl-2,3-dihydro-1H-isoindol-5-yl)1-methanol (127169-16-8)

Guidance literature:

Multi-step reaction with 3 steps

1: NBS; benzoyl peroxide / CCl₄ / Heating

2: Et₃N / benzene / Heating

3: LiAlH₄ / tetrahydrofuran / 25 °C

With N-Bromosuccinimide; lithium aluminium tetrahydride; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; benzene;

DOI:10.1016/j.bmcl.2005.03.020

Reference yield:

methyl 3,4-bis(bromomethyl)benzoate (20896-23-5) → (2-benzyl-2,3-dihydro-1H-isoindol-5-yl)1-methanol (127169-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / benzene / Heating

2: LiAlH₄ / tetrahydrofuran / 25 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; benzene;

DOI:10.1016/j.bmcl.2005.03.020

upstream raw materials:

methyl 2,3-dihydro-2-(phenylmethyl)-1H-isoindole-5-carboxylate

methyl 3,4-dimethylbenzoate

methyl 3,4-bis(bromomethyl)benzoate

Downstream raw materials:

5-hydroxymethyl-2,3-dihydro-1H-isoindole

tert-butyl 5-(hydroxymethyl)-1,3-dihydro-2H-isoindole-2-carboxylate

5-{[methyl-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-carbamoyl]-methyl}-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester