(R)-2-Methylbutyric Acid-d3

Base Information

• Chemical Name: (R)-2-Methylbutyric Acid-d3
• CAS No.: 1346617-08-0
• Molecular Formula: C₅H₁₀O₂
• Molecular Weight: 105.109
• Mol file: 1346617-08-0.mol

Synonyms:(R)-2-Methylbutyric Acid-d3;(-)-2-(Methyl-d3)butanoic Acid;(2R)-2-(Methyl-d3)butanoic Acid;(R)-(-)-2-(Methyl-d3)butanoic Acid

Chemical Property of (R)-2-Methylbutyric Acid-d3

Chemical Property:

• PSA: 37.30000
• LogP: 1.11710

Purity/Quality:

98% ^*data from raw suppliers

(R)-2-MethylbutyricAcid-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Labelled (R)-2-Methylbutyric Acid (M294365). (R)-2-Methylbutyric Acid is a metabolite of Ethyl (E)-2-methyl-2-butenoate (Ethyl tiglate), an important aroma compound in apples and serves as an indicator for genuineness of apple products due to its high optical purity of greater than 98% enantiomeric excess.

Technology Process of (R)-2-Methylbutyric Acid-d3

There total 5 articles about (R)-2-Methylbutyric Acid-d3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 2-methyl-d3 butyrate (181878-39-7) → 2-methylbutanoic-d3 acid (95926-92-4,1346617-08-0)

Guidance literature:

With sodium hydroxide; for 48h; Ambient temperature;

DOI:10.1021/jf9508209

Reference yield:

2-methylenebutyric acid (3586-58-1,62607-09-4) → 2-Methylbutanoic acid (116-53-0,600-07-7) + C5H8(2)H2O2 + C5H7(2)H3O2 + C5H4(2)H6O2 (1346617-08-0)

Guidance literature:

With 5%-palladium/activated carbon; water-d2; deuterium; benzylamine; Cinchonidin; In 1,4-dioxane; at 23 ℃; under 750.075 Torr; enantioselective reaction;

DOI:10.1246/bcsj.20190169

Reference yield:

Tiglic acid (80-59-1) → C5H8(2)H2O2 + C5H7(2)H3O2 + C5H4(2)H6O2 (1346617-08-0)

Guidance literature:

With 5%-palladium/activated carbon; water-d2; deuterium; benzylamine; Cinchonidin; In 1,4-dioxane; at 23 ℃; for 3h; under 750.075 Torr; Time; Pressure; enantioselective reaction;

DOI:10.1246/bcsj.20190169

upstream raw materials:

ethyl 2-methyl-d₃ butyrate

Tiglic acid

2-methylenebutyric acid

Refernces

• 1、 Friedman,Jurewicz. "-". . p. 1808. Retrieved 1969.
• 2、 Rowan, Daryl D.,Lane, Heather P.,Allen, John M.,Fielder, Simon,Hunt, Martin B.. "Biosynthesis of 2-Methylbutyl, 2-Methyl-2-butenyl, and 2-Methylbutanoate Esters in Red Delicious and Granny Smith Apples Using Deuterium-Labeled Substrates". . p. 3276 - 3285. Retrieved 2007/10/03.