E-Cefdinir

Base Information

Chemical Name:E-Cefdinir
CAS No.:178601-88-2
Molecular Formula:C₁₄H₁₃N₅O₅S₂
Molecular Weight:395.42
Hs Code.:
European Community (EC) Number:643-088-1
UNII:61G2M33IGF
Nikkaji Number:J227.563E
Wikipedia:Cefdinir
Wikidata:Q1453445
NCI Thesaurus Code:C28914
RXCUI:25037
Mol file:178601-88-2.mol

Synonyms:7-(2 (2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid;cefdinir;CI 983;CI-983;CI983;FK 482;FK-482;FK482;Omnicef;PD 134393;PD-134393

Suppliers and Price of E-Cefdinir

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(E)-Cefdinir
25mg
$ 4310.00

Medical Isotopes, Inc.
(E)-Cefdinir
5 mg
$ 5500.00

Biosynth Carbosynth
(Z)-Cefdinir
25 mg
$ 7500.00

Biosynth Carbosynth
(Z)-Cefdinir
10 mg
$ 4200.00

Biosynth Carbosynth
(Z)-Cefdinir
5 mg
$ 2625.00

American Custom Chemicals Corporation
(E)-CEFDINIR 95.00%
5MG
$ 496.11

AK Scientific
E-Cefdinir
25mg
$ 10175.00

Total 13 raw suppliers

Chemical Property of E-Cefdinir

Chemical Property:

PSA：215.97000
LogP:0.53650
Storage Temp.:Amber Vial, -20°C Freezer, Under Inert Atmosphere
Solubility.:Dichloromethane (Slightly), Methanol (Slightly)
XLogP3:0
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:5
Exact Mass:395.03581088
Heavy Atom Count:26
Complexity:739

Purity/Quality:

99% ^*data from raw suppliers

(E)-Cefdinir ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C=CC1=C(N2C(C(C2=O)NC(=O)C(=NO)C3=CSC(=N3)N)SC1)C(=O)O
Isomeric SMILES:C=CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N/O)/C3=CSC(=N3)N)SC1)C(=O)O
Recent ClinicalTrials:Trial to Evaluate Beta-Lactam Antimicrobial Therapy of Community Acquired Pneumonia in Children
Uses Cefdinir (C242670) impurity. The E-isomer of Cefdinir (C242670). (E)-Cefdinir (Cefdinir EP Impurity R) is a Cefdinir (C242670) impurity. The E-isomer of Cefdinir (C242670).

Technology Process of E-Cefdinir

There total 58 articles about E-Cefdinir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 7-amino-3-vinylcephalosporin-4-carboxylic acid p-nitrobenzyl ester

: 1-[(Z)-2-(2-amino-4-thiazolyl)-2-(acetoxyimino)acetoxy]benzotriazole

: 91832-40-5,178601-88-2
cefdinir

Guidance literature:: 7-amino-3-vinylcephalosporin-4-carboxylic acid p-nitrobenzyl ester; With N-cyclohexyl-cyclohexanamine; In water; isopropyl alcohol; acetonitrile; at 5 - 10 ℃; for 0.166667h;

1-[(Z)-2-(2-amino-4-thiazolyl)-2-(acetoxyimino)acetoxy]benzotriazole; In water; isopropyl alcohol; acetonitrile; at 20 ℃; Further stages;

Reference yield: 90.0%

: potassium syn-7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate tetrahydrate

: 91832-40-5,178601-88-2
cefdinir

Guidance literature:: With hydrogenchloride; In water; at 25 - 30 ℃; for 2h; pH=2.4 - 2.5;

Reference yield: 88.6%

: 104797-47-9
S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate

: 79349-82-9
(6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 91832-40-5,178601-88-2
cefdinir

Guidance literature:: S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate; (6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; With triethylamine; In tetrahydrofuran; at 20 - 23 ℃; for 5h;

With hydrogenchloride; methoxybenzene; In tetrahydrofuran; dichloromethane; at -25 - -20 ℃; for 1.5h;