Methanesulfonic acid, 1,1,1-trifluoro-, 2-[(1S)-1-[[(1,1-diMethylethoxy)carbonyl]aMino]-2-phenylethyl]-5-thiazolyl ester

Base Information

• Chemical Name: Methanesulfonic acid, 1,1,1-trifluoro-, 2-[(1S)-1-[[(1,1-diMethylethoxy)carbonyl]aMino]-2-phenylethyl]-5-thiazolyl ester
• CAS No.: 1355078-29-3
• Molecular Formula: C17H19F3N2O5S2
• Molecular Weight: 452.4683696
• Mol file: 1355078-29-3.mol

Synonyms:Methanesulfonic acid, 1,1,1-trifluoro-, 2-[(1S)-1-[[(1,1-diMethylethoxy)carbonyl]aMino]-2-phenylethyl]-5-thiazolyl ester;Methanesulfonic acid, 1,1,1-trifluoro-, 2-[(1S)-1-[[(1,1-diMethylethoxy)carbonyl]aMino]-2-phenylethyl]-5-thiazolyl ester-4

Chemical Property of Methanesulfonic acid, 1,1,1-trifluoro-, 2-[(1S)-1-[[(1,1-diMethylethoxy)carbonyl]aMino]-2-phenylethyl]-5-thiazolyl ester

Chemical Property:

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid, 1,1,1-trifluoro-, 2-[(1S)-1-[[(1,1-diMethylethoxy)carbonyl]aMino]-2-phenylethyl]-5-thiazolyl ester

There total 3 articles about Methanesulfonic acid, 1,1,1-trifluoro-, 2-[(1S)-1-[[(1,1-diMethylethoxy)carbonyl]aMino]-2-phenylethyl]-5-thiazolyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trifluoromethylsulfonic anhydride (358-23-6) + (S)-2-[2-(tert-butoxycarbonylamino)-3-phenylpropanethioamido]acetic acid → (S)-2-[1-(tert-butoxycarbonylamino)-2-phenylethyl]thiazol-5-yl trifluoromethanesulfonate (1355078-29-3)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1055/s-0031-1289594

Reference yield:

methyl 2-((2S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)acetate (7625-57-2) → (S)-2-[1-(tert-butoxycarbonylamino)-2-phenylethyl]thiazol-5-yl trifluoromethanesulfonate (1355078-29-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetraphosphorus decasulfide; sodium carbonate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol; water / 16 h / 0 - 20 °C / Inert atmosphere

2.2: pH 1 / Inert atmosphere

3.1: 4-methyl-morpholine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; tetraphosphorus decasulfide; sodium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1055/s-0031-1289594

Reference yield:

methyl (S)-(2-((tert-butoxycarbonyl)amino)-3-phenylpropanethioyl)glycinate (128421-85-2) → (S)-2-[1-(tert-butoxycarbonylamino)-2-phenylethyl]thiazol-5-yl trifluoromethanesulfonate (1355078-29-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol; water / 16 h / 0 - 20 °C / Inert atmosphere

1.2: pH 1 / Inert atmosphere

2.1: 4-methyl-morpholine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; sodium hydroxide; In methanol; dichloromethane; water;

DOI:10.1055/s-0031-1289594

upstream raw materials:

trifluoromethylsulfonic anhydride

methyl 2-((2S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)acetate

methyl (S)-(2-((tert-butoxycarbonyl)amino)-3-phenylpropanethioyl)glycinate

Downstream raw materials:

tert-butyl N-[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]carbamate