Technology Process of 4-(2,6-dimethyl-4-nitrophenoxy)-5-benzyl-2-chloro-5H-pyrrolo[3,2-d]pyrimidine
There total 10 articles about 4-(2,6-dimethyl-4-nitrophenoxy)-5-benzyl-2-chloro-5H-pyrrolo[3,2-d]pyrimidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,6-dimethyl-4-nitro phenol;
With
sodium hydride;
In
1-methyl-2-pyrridone;
at 20 ℃;
for 0.5h;
5-benzyl-2,4-dichloro-5H-pyrrolo<3,2-d>pyrimidine;
In
1-methyl-2-pyrridone;
at 90 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 20 °C
2.1: N,N-dimethyl-formamide / 3 h / 65 °C
3.1: sodium dithionite / tetrahydrofuran; water / 20 °C
4.1: sodium hydroxide; water / methanol / 5 h / 100 °C
5.1: ammonium formate / palladium 10% on activated carbon / methanol / 4 h / 75 °C
6.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 2 h / 0 - 20 °C
7.1: trichlorophosphate / 3 h / 116 °C
8.1: antimony(III) chloride / 1,2-dichloro-ethane / 0.08 h / -10 °C
8.2: 5 h / -10 - 20 °C
9.1: sodium hydride / 1-methyl-2-pyrridone / 0.5 h / 20 °C
9.2: 16 h / 90 °C
With
sodium hydroxide; sodium dithionite; tetrabutylammomium bromide; water; ammonium formate; antimony(III) chloride; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; 1-methyl-2-pyrridone; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide; water / methanol / 5 h / 100 °C
2.1: ammonium formate / palladium 10% on activated carbon / methanol / 4 h / 75 °C
3.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 2 h / 0 - 20 °C
4.1: trichlorophosphate / 3 h / 116 °C
5.1: antimony(III) chloride / 1,2-dichloro-ethane / 0.08 h / -10 °C
5.2: 5 h / -10 - 20 °C
6.1: sodium hydride / 1-methyl-2-pyrridone / 0.5 h / 20 °C
6.2: 16 h / 90 °C
With
sodium hydroxide; tetrabutylammomium bromide; water; ammonium formate; antimony(III) chloride; sodium hydride; trichlorophosphate;
palladium 10% on activated carbon;
In
methanol; 1-methyl-2-pyrridone; dichloromethane; water; 1,2-dichloro-ethane;
