2-(1-Benzylpyrrolidin-2-ylidene)-2-cyanoacetamide

Base Information

Chemical Name:2-(1-Benzylpyrrolidin-2-ylidene)-2-cyanoacetamide
CAS No.:66751-29-9
Molecular Formula:C₁₄H₁₅N₃O
Molecular Weight:241.293
Hs Code.:2933990090
DSSTox Substance ID:DTXSID50353634

Synonyms:2-(1-benzylpyrrolidin-2-ylidene)-2-cyanoacetamide;66751-29-9;DTXSID50353634

Suppliers and Price of 2-(1-Benzylpyrrolidin-2-ylidene)-2-cyanoacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-[1-BENZYLPYRROLIDINYLIDENE]-2-CYANO ACETAMIDE 95.00%
5MG
$ 497.95

Total 4 raw suppliers

Chemical Property of 2-(1-Benzylpyrrolidin-2-ylidene)-2-cyanoacetamide

Chemical Property:

PSA：71.11000
LogP:2.63298
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:241.121512110
Heavy Atom Count:18
Complexity:399

Purity/Quality:

96% ^*data from raw suppliers

2-[1-BENZYLPYRROLIDINYLIDENE]-2-CYANO ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=C(C#N)C(=O)N)N(C1)CC2=CC=CC=C2

Technology Process of 2-(1-Benzylpyrrolidin-2-ylidene)-2-cyanoacetamide

There total 1 articles about 2-(1-Benzylpyrrolidin-2-ylidene)-2-cyanoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66751-29-9
2-[1-Benzyl-pyrrolidin-(2E)-ylidene]-2-cyano-acetamide

Guidance literature:: /BRN= 132168/ (IX), 1. Dimethylsulfat, 2. NaOCH3, 3. NCCH2CONH2;
DOI:10.1007/BF00470561

Reference yield: 85.0%

: 67751-11-5
N,N,N',N'-Tetramethylharnstoff-diethylacetal

: 66751-29-9
1-benzyl-2-(cyanocarbamoylmethylene)pyrrolidine

: 78394-58-8
1-Benzyl-2-pyrrolidine

Guidance literature:: at 120 - 125 ℃; for 1.5h;
DOI:10.1007/BF00507248

Reference yield:

: 66751-29-9
1-benzyl-2-(cyanocarbamoylmethylene)pyrrolidine

: 78394-63-5
1-Benzyl-4-dimethylamino-7-cyano-5-azaindoline

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / 1.5 h / 120 - 125 °C

2: 64 percent / 1 h / 200 - 205 °C

3: 100 percent / POCl₃ / 0.17 h / Heating

4: 39 percent / H₂ / 6percent Pd on carbon / ethanol / 40 h / standard conditions

With hydrogen; trichlorophosphate; palladium on activated charcoal; In ethanol;
DOI:10.1007/BF00507248