Interferonbeta1a/Humaninterferonbeta1a

Base Information

• Chemical Name: Interferonbeta1a/Humaninterferonbeta1a
• CAS No.: 145258-61-3
• Molecular Weight: 0
• Mol file: 145258-61-3.mol

Synonyms:Interferonbeta-1a; Neoferon

Chemical Property of Interferonbeta1a/Humaninterferonbeta1a

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: -70°C

Purity/Quality:

99% ^*data from raw suppliers

IFN-beta ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Launched in the US for relapsing forms of multiple sclerosis (MS), interferon β-1a is the second compound to be marketed for MS next to interferon p-lb (Betaseron). This form of p-interferon is a glycosylated polypeptide of 166 amino acids (sequence identical to human) produced from cultured Chinese hamster ovary cells containing the engineered human gene for interferon β-1a. The difference in structure to interferon β-1b lies in the substitution of a cysteine for a serine and in the fact it is glycosylated. The I b form requires reconstitution and subcutaneous injection every other day, while the l a form is an intramuscular injection once a week. The exact mode of action for the β-interferons has not been delineated, however, it is thought that they reverse a suppressor cell defect and favor the generation of T helper-2 type responses. It is presumed that the immunoregulatory and antiviral actions, in addition to the antagonistic effect they have on γ-interferon (γ-interferon has been shown to exacerbate the symptoms of MS), provide an overall beneficial effect.
• Uses: Antineoplastic; biological response modifier.