5-BROMO-3-IODO-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLICACIDTERT-BUTYLESTER

Base Information

• Chemical Name: 5-BROMO-3-IODO-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLICACIDTERT-BUTYLESTER
• CAS No.: 928653-81-0
• Molecular Formula: C₁₂H₁₂BrIN₂O₂
• Molecular Weight: 423.048
• Hs Code.: 2933990090
• Mol file: 928653-81-0.mol

Synonyms:1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 5-bromo-3-iodo-, 1,1-dimethylethyl ester

Chemical Property of 5-BROMO-3-IODO-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLICACIDTERT-BUTYLESTER

Chemical Property:

• Vapor Pressure: 1.5E-07mmHg at 25°C
• Boiling Point: 428.6°C at 760 mmHg
• Flash Point: 213°C
• PSA: 44.12000
• Density: 1.91g/cm³
• LogP: 4.18660

Purity/Quality:

99%, ^*data from raw suppliers

5-Bromo-3-iodo-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-3-IODO-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLICACIDTERT-BUTYLESTER

There total 3 articles about 5-BROMO-3-IODO-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLICACIDTERT-BUTYLESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 5-bromo-1H-pyrrolo[2,3-b]pyridine (183208-35-7) → 5-bromo-3-iodo-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester (928653-81-0)

Guidance literature:

5-bromo-1H-pyrrolo[2,3-b]pyridine; With N-iodo-succinimide; In tetrahydrofuran; at 20 ℃; for 2h;

di-tert-butyl dicarbonate; With triethylamine; In tetrahydrofuran; at 60 ℃; for 4h;

Reference yield: 95.0%

3-iodo-5-bromo-1H-pyrrolo[2,3-b]-pyridine (757978-18-0) + di-tert-butyl dicarbonate (24424-99-5) → 5-bromo-3-iodo-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester (928653-81-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

5-bromo-1H-pyrrolo[2,3-b]pyridine (183208-35-7) → 5-bromo-3-iodo-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester (928653-81-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 20 °C

2: dmap; triethylamine / dichloromethane / 2 h / 20 °C

With dmap; N-iodo-succinimide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

5-bromo-1H-pyrrolo[2,3-b]pyridine

3-iodo-5-bromo-1H-pyrrolo[2,3-b]-pyridine

di-tert-butyl dicarbonate

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