3-HYDROXYOCTANOIC ACID

Base Information

• Chemical Name: 3-HYDROXYOCTANOIC ACID
• CAS No.: 88930-08-9
• Molecular Formula: C₈H₁₆O₃
• Molecular Weight: 160.213
• Hs Code.: 2918199090
• Mol file: 88930-08-9.mol

Synonyms:DL-BETA-HYDROXYCAPRYLIC ACID;3-HYDROXY C8:0 ACID;(+/-)-3-HYDROXYOCTANOIC ACID;3-HYDROXYOCTANOIC ACID;dl-B-hydroxycaprylic acid;dl-β-hydroxycaprylic acid

Chemical Property of 3-HYDROXYOCTANOIC ACID

Chemical Property:

• PSA: 57.53000
• LogP: 1.40230
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Hydroxyoctanoic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-HYDROXYOCTANOIC ACID

There total 8 articles about 3-HYDROXYOCTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-hydroxyoctanoic acid methyl ester (7367-87-5,85549-54-8) → 3-hydroxyoctanoic acid (33796-86-0,44987-72-6,88930-08-9,14292-27-4,120659-38-3)

Guidance literature:

With methanol; potassium hydroxide; In hexane; at 50 - 60 ℃; for 0.5h;

DOI:10.1055/s-0034-1379479

Reference yield: 70.0%

ethyl β-hydroxyoctanoate (7367-90-0,96854-38-5,112138-04-2,118918-31-3) → 3-hydroxyoctanoic acid (33796-86-0,44987-72-6,88930-08-9,14292-27-4,120659-38-3)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2014.05.107

Reference yield: 68.0%

hexanal (66-25-1) → 3-hydroxyoctanoic acid (33796-86-0,44987-72-6,88930-08-9,14292-27-4,120659-38-3)

Guidance literature:

With hydrogenchloride; n-butyllithium; acetic acid; diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane;

upstream raw materials:

methyl 3-oxooctanoate

hexanal

ethyl bromoacetate

ethyl 3-oxooctanoate

Downstream raw materials:

N-(3-hydroxyoctanoyl)-L-homoserine lactone

3-hydroxyoctanoic acid methyl ester

2-acetoacetic acid

Refernces

• 1、 Singh, Renu,Reynolds, Kevin A.. "Characterization of FabG and FabI of the Streptomyces coelicolor dissociated fatty acid synthase". . p. 631 - 640. Retrieved 2015/03/31.
• 2、 Kitir, Betül,Baldry, Mara,Ingmer, Hanne,Olsen, Christian A.. "Total synthesis and structural validation of cyclodepsipeptides solonamide A and B". . p. 7721 - 7732. Retrieved 2014/12/10.