Acebilustat

Base Information

• Chemical Name: Acebilustat
• CAS No.: 943764-99-6
• Molecular Formula: C₂₉H₂₇N₃O₄
• Molecular Weight: 481.551
• Mol file: 943764-99-6.mol

Synonyms:Acebilustat

Chemical Property of Acebilustat

Chemical Property:

• PSA: 79.04000
• LogP: 5.16660
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

98% ^*data from raw suppliers

Acebilustat(ZK322) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Acebilustat (also known as CTX-4430) is a new once-daily oral anti-inflammatory drug in development for treatment of cystic fibrosis (CF) and other diseases. It is an inhibitor of leukotriene A4 hydrolase, which is responsible for the production of leukotriene B4 (LTB4). The later is a molecule that leads to inflammation. Therefore, Acebilustat can treat inflammation through suppressing the production of leukotriene B4.

Technology Process of Acebilustat

There total 1 articles about Acebilustat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methyl 4-[[(1S,4S)-5-[[4-[4-(2-oxazolyl)phenoxy]phenyl]methyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]benzoate → 4-{[(1S,4S)-5-({4-[4-oxazol-2-yl-phenoxy]phenyl}methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl}benzoic acid (943764-99-6)

Guidance literature:

methyl 4-[[(1S,4S)-5-[[4-[4-(2-oxazolyl)phenoxy]phenyl]methyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]benzoate; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; pH=8;

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