CAY10603

Base Information

• Chemical Name: CAY10603
• CAS No.: 1045792-66-2
• Molecular Formula: C22H30N4O6
• Molecular Weight: 446.503
• Mol file: 1045792-66-2.mol

Synonyms:CAY10603;Isox;tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate;HDAC6 Inhibitor;N-[4-[3-[[[7-(Hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]carbamic acid 1,1-dimethylethyl ester;HDAC6 inhibitor ISOX

Chemical Property of CAY10603

Chemical Property:

• PKA: 9.47±0.20(Predicted)
• PSA: 142.79000
• Density: 1.231±0.06 g/cm3(Predicted)
• LogP: 4.72910
• Storage Temp.: +2C to +8C
• Solubility.: ≥22.35 mg/mL in DMSO; insoluble in EtOH; ≥24.85 mg/mL in H2O

Purity/Quality:

98%min ^*data from raw suppliers

HDAC6Inhibitor ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively). Also, CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM). The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).

Technology Process of CAY10603

There total 1 articles about CAY10603 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

7-{[5-(4-tert-butoxycarbonylaminophenyl)isoxazole-3-carbonyl]amino}heptanoic acid methyl ester (1045792-87-7) → CAY10603 (1045792-66-2)

Guidance literature:

With potassium hydroxide; hydroxylamine hydrochloride; In methanol; at 20 ℃; for 0.5h;

DOI:10.1021/jm8002894

upstream raw materials:

7-{[5-(4-tert-butoxycarbonylaminophenyl)isoxazole-3-carbonyl]amino}heptanoic acid methyl ester

Refernces