2,2-Dimethyl-1-[4-(trifluoromethoxy)phenyl]propan-1-one

Base Information

• Chemical Name: 2,2-Dimethyl-1-[4-(trifluoromethoxy)phenyl]propan-1-one
• CAS No.: 1263313-09-2
• Molecular Formula: C12H13F3O2
• Molecular Weight: 246.229
• Hs Code.: 2914700090
• Mol file: 1263313-09-2.mol

Synonyms:2,2-Dimethyl-1-[4-(trifluoromethoxy)phenyl]propan-1-one;t-Butyl 4-(trifluoromethoxy)phenyl ketone

Chemical Property of 2,2-Dimethyl-1-[4-(trifluoromethoxy)phenyl]propan-1-one

Chemical Property:

• Boiling Point: 260.3±35.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.167±0.06 g/cm3(Predicted)
• LogP: 3.81400

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

t-Butyl4-(trifluoromethoxy)phenylketone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-Dimethyl-1-[4-(trifluoromethoxy)phenyl]propan-1-one

There total 1 articles about 2,2-Dimethyl-1-[4-(trifluoromethoxy)phenyl]propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

p-trifluoromethoxybenzaldehyde (659-28-9) + 1,3-dioxoisoindolin-2-yl 3,3-dimethylbutanoate (84379-72-6) → 2,2-dimethyl-1-[4-(trifluoromethoxy)phenyl]propan-1-one (1263313-09-2)

Guidance literature:

With 3-(2,6-diisopropylphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-3-ium perchlorate; caesium carbonate; In dimethyl sulfoxide; at 60 ℃; for 4h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/jacs.9b00880

Reference yield: 76.0%

4-Chlorobenzenesulfonamide (98-64-6) + 2,2-dimethyl-1-[4-(trifluoromethoxy)phenyl]propan-1-one (1263313-09-2) → 4-chloro-N-[2-(2,2-dimethyl-propionyl)-5-trifluoromethoxy-phenyl]-benzenesulfonamide (1263313-21-8)

Guidance literature:

With palladium(II) bis(trifluoromethanesulfonate) dihydrate; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; In dichloromethane; at 80 ℃; for 8h;

DOI:10.1021/ja108450m

upstream raw materials:

p-trifluoromethoxybenzaldehyde

1,3-dioxoisoindolin-2-yl 3,3-dimethylbutanoate

Downstream raw materials:

4-chloro-N-[2-(2,2-dimethyl-propionyl)-5-trifluoromethoxy-phenyl]-benzenesulfonamide