tert-Butyl 4-(4-Methylpiperazin-1-yl)benzylcarbaMate

Base Information

• Chemical Name: tert-Butyl 4-(4-Methylpiperazin-1-yl)benzylcarbaMate
• CAS No.: 927676-52-6
• Molecular Formula: C17H27N3O2
• Molecular Weight: 305.42
• Mol file: 927676-52-6.mol

Synonyms:tert-Butyl 4-(4-Methylpiperazin-1-yl)benzylcarbaMate

Chemical Property of tert-Butyl 4-(4-Methylpiperazin-1-yl)benzylcarbaMate

Chemical Property:

• Boiling Point: 457.9±45.0 °C (760 mmHg)
• PSA: 44.81000
• Density: 1.075±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 2.85690
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-(4-methylpiperazin-1-yl)benzylcarbamate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 4-(4-Methylpiperazin-1-yl)benzylcarbaMate

There total 1 articles about tert-Butyl 4-(4-Methylpiperazin-1-yl)benzylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(4-(4-methylpiperazin-1-yl)phenyl)methanamine (216144-45-5) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-(4-methylpiperazin-1-yl)benzylcarbamate (927676-52-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1h;

Reference yield:

tert-butyl 4-(4-methylpiperazin-1-yl)benzylcarbamate (927676-52-6) → tert-butyl 3-chloro-4-(4-methylpiperazin-1-yl)benzylcarbamate (927676-53-7)

Guidance literature:

With N-chloro-succinimide; In dichloromethane; at 20 ℃; for 4h;

upstream raw materials:

(4-(4-methylpiperazin-1-yl)phenyl)methanamine

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl 3-chloro-4-(4-methylpiperazin-1-yl)benzylcarbamate

Refernces