Carbamic acid, N-[(1S)-2-(4-bromophenyl)-1-formylethyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, N-[(1S)-2-(4-bromophenyl)-1-formylethyl]-, 1,1-dimethylethyl ester
CAS No.:949886-36-6
Molecular Formula:C₁₄H₁₈BrNO₃
Molecular Weight:328.206
Hs Code.:

Synonyms:Carbamic acid, N-[(1S)-2-(4-bromophenyl)-1-formylethyl]-, 1,1-dimethylethyl ester;949886-36-6;SCHEMBL14884627;SB48719

Suppliers and Price of Carbamic acid, N-[(1S)-2-(4-bromophenyl)-1-formylethyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of Carbamic acid, N-[(1S)-2-(4-bromophenyl)-1-formylethyl]-, 1,1-dimethylethyl ester

Chemical Property:

PSA：55.40000
LogP:3.47470
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:327.04701
Heavy Atom Count:19
Complexity:306

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC1=CC=C(C=C1)Br)C=O

Technology Process of Carbamic acid, N-[(1S)-2-(4-bromophenyl)-1-formylethyl]-, 1,1-dimethylethyl ester

There total 2 articles about Carbamic acid, N-[(1S)-2-(4-bromophenyl)-1-formylethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 949885-93-2
[2-(4-bromo-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester

: 949886-36-6
[2-(4-bromo-phenyl)-1-formyl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃;
DOI:10.1016/j.bmcl.2005.08.064

Reference yield:

: 62129-39-9,79561-82-3
4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine

: 949886-36-6
[2-(4-bromo-phenyl)-1-formyl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / EDCI; NMM / CH₂Cl₂ / 0 - 20 °C

2: LiALH₄ / diethyl ether / 0 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In diethyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2005.08.064

Reference yield:

: 949886-36-6
[2-(4-bromo-phenyl)-1-formyl-ethyl]-carbamic acid tert-butyl ester

: (S)-2-Amino-3-methyl-butyric acid (S)-2-amino-3-(4-bromo-phenyl)-1-ethylcarbamoyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 20 °C

2: TFA / CH₂Cl₂ / 0 - 20 °C

With trifluoroacetic acid; In dichloromethane; 1: Passerini reaction;
DOI:10.1016/j.bmcl.2005.08.064