2-Azabicyclo[2.2.1]heptane-2-butanenitrile

Base Information

• Chemical Name: 2-Azabicyclo[2.2.1]heptane-2-butanenitrile
• CAS No.: 947263-49-2
• Molecular Formula: C₁₀H₁₆N₂
• Molecular Weight: 164.25
• Mol file: 947263-49-2.mol

Synonyms:2-Azabicyclo[2.2.1]heptane-2-butanenitrile

Chemical Property of 2-Azabicyclo[2.2.1]heptane-2-butanenitrile

Chemical Property:

• PSA: 27.03000
• LogP: 1.71238

Purity/Quality:

2-Azabicyclo[2.2.1]heptane-2-butanenitrile 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Azabicyclo[2.2.1]heptane-2-butanenitrile

There total 1 articles about 2-Azabicyclo[2.2.1]heptane-2-butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-aza-bicyclo[2.2.1]heptane (279-24-3) + 4-bromobutanenitrile (5332-06-9) → 4-(2-azanorborn-2-yl)butyronitrile (947263-49-2)

Guidance literature:

With potassium carbonate; potassium iodide; In butan-1-ol; for 20h; Heating;

DOI:10.1021/jm0701627

Reference yield:

4-(2-azanorborn-2-yl)butyronitrile (947263-49-2) → 4-acetamido-N-(4-(2-azanorborn-2-yl)butyl)-2-methoxybenzamide (947263-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

2: 0.76 g / triethylamine / tetrahydrofuran / 2 h

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jm0701627

Reference yield:

4-(2-azanorborn-2-yl)butyronitrile (947263-49-2) → C20H28IN3O3

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

2: 0.94 g / triethylamine / tetrahydrofuran / 2 h

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jm0701627

upstream raw materials:

2-aza-bicyclo[2.2.1]heptane

4-bromobutanenitrile

Downstream raw materials:

4-acetamido-N-(4-(2-azanorborn-2-yl)butyl)-2-methoxybenzamide