[(4-Methoxy-2-nitrophenyl)methyl]triphenyl-phosphonium Bromide

Base Information

Chemical Name:[(4-Methoxy-2-nitrophenyl)methyl]triphenyl-phosphonium Bromide
CAS No.:886442-56-4
Molecular Formula:Br*C₂₆H₂₃NO₃P
Molecular Weight:508.351
Hs Code.:
Mol file:886442-56-4.mol

Synonyms:[(4-Methoxy-2-nitrophenyl)methyl]triphenyl-phosphonium Bromide

Suppliers and Price of [(4-Methoxy-2-nitrophenyl)methyl]triphenyl-phosphonium Bromide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
((4-METHOXY-2-NITROPHENYL)METHYL)TRIPHENYL-PHOSPHONIUM BROMIDE 95.00%
500MG
$ 1871.10

American Custom Chemicals Corporation
((4-METHOXY-2-NITROPHENYL)METHYL)TRIPHENYL-PHOSPHONIUM BROMIDE 95.00%
50MG
$ 739.20

Total 2 raw suppliers

Chemical Property of [(4-Methoxy-2-nitrophenyl)methyl]triphenyl-phosphonium Bromide

Chemical Property:

PSA：68.64000
LogP:2.62470
Solubility.:Methanol

Purity/Quality:

97% ^*data from raw suppliers

((4-METHOXY-2-NITROPHENYL)METHYL)TRIPHENYL-PHOSPHONIUM BROMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses [(4-Methoxy-2-nitrophenyl)methyl]triphenyl-phosphonium Bromide is used in the production of substituted stilbenes [(4-Methoxy-2-nitrophenyl)methyl]triphenylphosphonium bromide is used in the synthesis of Combretastatin A4 (C643000) substituents (nitro or serinamide substituents) as inhibitors of tubulin assembly and vascular disrupting agents.

Technology Process of [(4-Methoxy-2-nitrophenyl)methyl]triphenyl-phosphonium Bromide

There total 2 articles about [(4-Methoxy-2-nitrophenyl)methyl]triphenyl-phosphonium Bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 57559-52-1
4-methoxy-2-nitrobenzyl bromide

: 603-35-0
triphenylphosphine

: 886442-56-4
(4-methoxy-2-nitrobenzyl)triphenylphosphonium bromide

Guidance literature:: In dichloromethane; for 16h; Heating;
DOI:10.1016/j.bmc.2005.12.033

Reference yield:

: 17484-36-5
4-Methyl-3-nitroanisole

: 886442-56-4
(4-methoxy-2-nitrobenzyl)triphenylphosphonium bromide

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / N-bromosuccinimide; 2,2'-azobisisobutyronitrile / CCl₄ / 16 h / Heating

2: 95 percent / CH₂Cl₂ / 16 h / Heating

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; dichloromethane;
DOI:10.1016/j.bmc.2005.12.033

Reference yield:

: 886442-56-4
(4-methoxy-2-nitrobenzyl)triphenylphosphonium bromide

: benzyl (3R,4R,5R,1E)-4-(tert-butyldimethylsilyloxy)-1-(4-methoxy-2-nitrophenyl)-6-(4-methoxybenzyloxy)-5-methylhex-1-en-3-ylcarbamate

: benzyl (3R,4R,5R,1Z)-4-(tert-butyldimethylsilyloxy)-1-(4-methoxy-2-nitrophenyl)-6-(4-methoxybenzyloxy)-5-methylhex-1-en-3-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / dichloromethane; mineral oil / 2 h / 0 °C

2: dichloromethane / 6 h / 20 °C

With sodium hydride; In dichloromethane; mineral oil; 2: |Wittig Olefination;
DOI:10.1016/j.tetlet.2013.02.032