(-)-cis-Cyclazocine

Base Information

Chemical Name:(-)-cis-Cyclazocine
CAS No.:7313-86-2
Molecular Formula:C₁₈H₂₅NO
Molecular Weight:271.403
Hs Code.:
European Community (EC) Number:264-552-6
UNII:RY2XTW4OJO
Nikkaji Number:J83.295B
Pharos Ligand ID:5DAZ4PYZGS2C
ChEMBL ID:CHEMBL56585
Mol file:7313-86-2.mol

Synonyms:(-)-cis-Cyclazocine;l-Cyclazocine;EINECS 264-552-6;Cyclazocine, (-)-;RY2XTW4OJO;63903-61-7;CHEMBL56585;MCV-4512;NIH-10450;(2alpha,6alpha,11R*)-3-(Cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-2,6-methano-3-benzazocin-8-ol;alpha-5,9-Dimethyl-2'-hydroxy-2(N)-cyclopropylmethyl-6,7-benzomorphan;2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-3-cyclopropylmethyl-6,11-alpha-dimethyl-,;(2R,6R,11R)-3-(Cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-2,6-methano-3-benzazocin-8-ol;2,6-Methano-3-benzazocin-8-ol, 3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-, (2R,6R,11R)-;WIN-20740;CC12CCN(CC3CC3)C(Cc4ccc(O)cc14)C2C;(-)-alpha-Cyclazocine;UNII-RY2XTW4OJO;SCHEMBL16557078;3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol;(-)-.ALPHA.-CYCLAZOCINE;2,6-Methano-3-benzazocin-8-ol, 3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-, (2.alpha.,6.alpha.,11R*)-;2,6-Methano-3-benzazocin-8-ol,3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-,(2R,6R,11R)-rel-;BDBM50001023;PDSP1_000956;NSC 172134;LS-90564;(2R,6R,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol;2,6-Methano-3-benzazocin-8-ol, 3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-, (2R,6R,11R)-rel-

Suppliers and Price of (-)-cis-Cyclazocine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(-)-Cyclazocine
10mg
$ 180.00

Medical Isotopes, Inc.
(-)-Cyclazocine
2.5 mg
$ 675.00

Biosynth Carbosynth
(-)-Cyclazocine
5 mg
$ 174.90

Biosynth Carbosynth
(-)-Cyclazocine
25 mg
$ 578.50

Biosynth Carbosynth
(-)-Cyclazocine
100 mg
$ 1911.00

Biosynth Carbosynth
(-)-Cyclazocine
50 mg
$ 1051.50

Biosynth Carbosynth
(-)-Cyclazocine
10 mg
$ 318.00

American Custom Chemicals Corporation
(-)-CYCLAZOCINE 95.00%
100MG
$ 2194.50

American Custom Chemicals Corporation
(-)-CYCLAZOCINE 95.00%
10MG
$ 367.50

Total 4 raw suppliers

Chemical Property of (-)-cis-Cyclazocine

Chemical Property:

Melting Point:188-190°C
PSA：23.47000
LogP:3.26430
Storage Temp.:-20°C Freezer
Solubility.:Chloroform, Ethanol, Methanol
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:271.193614421
Heavy Atom Count:20
Complexity:380

Purity/Quality:

97% ^*data from raw suppliers

(-)-Cyclazocine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C2CC3=C(C1(CCN2CC4CC4)C)C=C(C=C3)O
Isomeric SMILES:C[C@H]1[C@H]2CC3=C([C@@]1(CCN2CC4CC4)C)C=C(C=C3)O
Uses Cyclazocine is a mu opioid antagonist and kappa opioid agonist; it blocks the dopamine response to nicotine. Cyclazocine is a mu opioid antagonist and kappa opioid agonist; it blocks the dopamine response to nicotine

Technology Process of (-)-cis-Cyclazocine

There total 1 articles about (-)-cis-Cyclazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 16603-67-1,16670-83-0,16670-84-1,16670-86-3,16671-00-4,16808-63-2,25144-77-8,25144-78-9,52079-30-8
(-)-cis-N-Normetazocine

: 7051-34-5
cyclopropylcarbinyl bromide

: 3572-80-3,7313-86-2,7313-87-3,7346-09-0,13517-64-1,21820-30-4,21820-35-9,63903-61-7
(-)-Cyclazocine

Guidance literature:: With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 100 ℃; for 24h;
DOI:10.1002/jhet.5570270753

Reference yield:

: 7313-86-2
(+)-cyclazocine

: 3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-cis-6,11-dimethyl-8-<(phenylmethyl)amino>-2,6-methano-3-benzazocine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 0 - 25 °C

2: 53 percent / Pd(OAc)2; BINAP; NaOtBu / toluene / 8 h / 80 °C

With pyridine; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In dichloromethane; toluene;
DOI:10.1021/jm020429w

Reference yield:

: 7313-86-2
(+)-cyclazocine

: (2R,6R,11R)-3-(cyclopropylmethyl)-N-(diphenylmethylene)-1,2,3,4,5,6-hexahydro-cis-6,11-dimethyl-2,6-methano-3-benzazocin-8-amine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 0 - 25 °C

2: Pd₂(dba)3; DPPF; NaOtBu / toluene / 80 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; sodium t-butanolate; In dichloromethane; toluene;
DOI:10.1021/jm020429w