6-((diMethylaMino)Methyl)-5,6,7,8-tetrahydronaphthalen-2-aMine

Base Information

• Chemical Name: 6-((diMethylaMino)Methyl)-5,6,7,8-tetrahydronaphthalen-2-aMine
• CAS No.: 331754-31-5
• Molecular Formula: C13H20N2
• Molecular Weight: 204.315
• Mol file: 331754-31-5.mol

Synonyms:6-((diMethylaMino)Methyl)-5,6,7,8-tetrahydronaphthalen-2-aMine;6-Amino-2-(N,N-dimethylamino)methyltetralin;[(6-aMino-1,2,3,4-tetrahydro-2-naphthalenyl)Methyl]diMethylaMine;6-amino-1,2,3,4-tetrahydro-N,N-dimethyl-2-Naphthalenemethan amine

Chemical Property of 6-((diMethylaMino)Methyl)-5,6,7,8-tetrahydronaphthalen-2-aMine

Chemical Property:

• Boiling Point: 336℃
• Flash Point: 141℃
• PSA: 29.26000
• Density: 1.022
• LogP: 2.51650

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-((diMethylaMino)Methyl)-5,6,7,8-tetrahydronaphthalen-2-aMine

There total 5 articles about 6-((diMethylaMino)Methyl)-5,6,7,8-tetrahydronaphthalen-2-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(6-dimethylaminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetamide hydrochloride → [(6-amino-1,2,3,4-tetrahydro-2-naphthalenyl)methyl]dimethylamine (331754-31-5)

Guidance literature:

N-(6-dimethylaminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetamide hydrochloride; With hydrogenchloride; In water; Heating / reflux;

With sodium carbonate;

Reference yield: 54.0%

6-[(dimethylamino)methyl]-7,8-dihydro-2-naphthalenamine (331760-35-1) → [(6-amino-1,2,3,4-tetrahydro-2-naphthalenyl)methyl]dimethylamine (331754-31-5)

Guidance literature:

6-[(dimethylamino)methyl]-7,8-dihydro-2-naphthalenamine; With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; for 4h;

With potassium carbonate; In water;

DOI:10.1016/j.bmc.2011.07.038

Reference yield:

6-amino-2-[(dimethylamino)methylidene]-3,4-dihydro-1(2H)-naphthalenone → [(6-amino-1,2,3,4-tetrahydro-2-naphthalenyl)methyl]dimethylamine (331754-31-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 0.5 h / Cooling with ice

1.2: 1 h / Cooling with ice

2.1: hydrogenchloride; water / 6 h / 100 °C

3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 4 h

With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.bmc.2011.07.038

upstream raw materials:

6-[(dimethylamino)methyl]-7,8-dihydro-2-naphthalenamine

Downstream raw materials:

4'-chloro-N-[6-[(N,N-diethylamino)methyl]-7,8-dihydro-2-naphthalenyl][1,1'-biphenyl]-4-carboxamide

4'-chloro-N-[6-[(4-methyl-1-piperazinyl)methyl]-7,8-dihydro-2-naphthalenyl][1,1'-biphenyl]-4-carboxamide