Pfhmv-D3

Base Information

Chemical Name:Pfhmv-D3
CAS No.:119839-97-3
Molecular Formula:C₂₈H₄₁F₅O₃
Molecular Weight:520.624
Hs Code.:
Mol file:119839-97-3.mol

Synonyms:26,26,26,27,27-pentafluoro-1-hydroxy-27-methoxyvitamin D3;PFHMV-D3

Suppliers and Price of Pfhmv-D3

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Pfhmv-D3

Chemical Property:

Vapor Pressure:7.11E-14mmHg at 25°C
Boiling Point:539.2°Cat760mmHg
Flash Point:230.5°C
PSA：49.69000
Density:1.17g/cm³
LogP:7.35150
XLogP3:7.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:520.29758598
Heavy Atom Count:36
Complexity:849

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CCCC(C(OC)(F)F)C(F)(F)F)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
Isomeric SMILES:C[C@H](CCCC(C(OC)(F)F)C(F)(F)F)C1CCC\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](CC(C3=C)O)O)C

Technology Process of Pfhmv-D3

There total 5 articles about Pfhmv-D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 119839-96-2
26,26,26,27,27-pentafluoro-1α,3β-dihydroxy-27-methoxycholesta-5,7-diene

: 119839-97-3
26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D₃

Guidance literature:: In ethanol; benzene; 1.) irrad., 5 min; 2.) reflux, 1 h;
DOI:10.1248/cpb.36.4144

Reference yield:

: 103742-62-7
1α,3β-diacetoxychol-5-en-24-al

: 119839-97-3
26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D₃

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine / diethyl ether / 16 h / -78 °C

2: 51 percent / sodium borohydride / tetrahydrofuran; 2-methyl-propan-2-ol / 22 h / Ambient temperature

3: 1.) N-bromosuccinimide; 2.) collidine/xylene / CCl₄ / 1.) reflux, 25 min; 2.) reflux, 20 min

4: 20 percent / 5percent potassium hydroxyde / tetrahydrofuran / 1 h / Ambient temperature

5: 15 percent / benzene; ethanol / 1.) irrad., 5 min; 2.) reflux, 1 h

With 2,3,5-trimethyl-pyridine; potassium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; triphenylphosphine; xylene; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; tert-butyl alcohol; benzene;
DOI:10.1248/cpb.36.4144

Reference yield:

: 106014-55-5
1α-acetoxy-26,26,26,27,27,27-hexafluorocholesterol 3β-acetate

: 119839-97-3
26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D₃

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N-bromosuccinimide; 2.) collidine/xylene / CCl₄ / 1.) reflux, 25 min; 2.) reflux, 20 min

2: 20 percent / 5percent potassium hydroxyde / tetrahydrofuran / 1 h / Ambient temperature

3: 15 percent / benzene; ethanol / 1.) irrad., 5 min; 2.) reflux, 1 h

With 2,3,5-trimethyl-pyridine; potassium hydroxide; N-Bromosuccinimide; xylene; In tetrahydrofuran; tetrachloromethane; ethanol; benzene;
DOI:10.1248/cpb.36.4144