2-(2-Methoxyethyl)pyrrolidine

Base Information

• Chemical Name: 2-(2-Methoxyethyl)pyrrolidine
• CAS No.: 933746-73-7
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.202
• Hs Code.: 2933990090
• European Community (EC) Number: 869-174-0
• Mol file: 933746-73-7.mol

Synonyms:2-(2-methoxyethyl)pyrrolidine;933746-73-7;MFCD19102570;SCHEMBL10103537;AKOS013406695;SB11938;AS-34036;CS-0052298;FT-0724998;EN300-1600802

Chemical Property of 2-(2-Methoxyethyl)pyrrolidine

Chemical Property:

• Boiling Point: 165.4±13.0 °C(Predicted)
• PKA: 10.69±0.10(Predicted)
• PSA: 21.26000
• Density: 0.889±0.06 g/cm3(Predicted)
• LogP: 1.10370
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 129.115364102
• Heavy Atom Count: 9
• Complexity: 75.3

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Methoxyethyl)pyrrolidine 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCC1CCCN1

Technology Process of 2-(2-Methoxyethyl)pyrrolidine

There total 3 articles about 2-(2-Methoxyethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-tert-butyloxycarbonyl-2-(2-methoxyethyl)pyrrolidine (1428534-90-0) → (S)-2-(2-methoxyethyl)pyrrolidine (933746-73-7)

Guidance literature:

(S)-N-tert-butyloxycarbonyl-2-(2-methoxyethyl)pyrrolidine; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2.5h; Inert atmosphere;

With sodium hydroxide; In dichloromethane; water; Inert atmosphere;

DOI:10.1016/j.bmc.2013.01.011

Reference yield:

(2S)-1-tert-butoxycarbonyl-2-carboxymethylpyrrolidine (56502-01-3) → (S)-2-(2-methoxyethyl)pyrrolidine (933746-73-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.25 h / -10 °C / Inert atmosphere

2.2: -10 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

3.2: Inert atmosphere

With dimethylsulfide borane complex; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmc.2013.01.011

Reference yield:

(2S)-tert-butyl 2-(2-hydroxyethyl)pyrrolidine-1-carboxylate (88790-38-9,220312-34-5) → (S)-2-(2-methoxyethyl)pyrrolidine (933746-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / -10 °C / Inert atmosphere

1.2: -10 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: Inert atmosphere

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmc.2013.01.011

upstream raw materials:

(2S)-1-tert-butoxycarbonyl-2-carboxymethylpyrrolidine

(2S)-tert-butyl 2-(2-hydroxyethyl)pyrrolidine-1-carboxylate

(S)-N-tert-butyloxycarbonyl-2-(2-methoxyethyl)pyrrolidine