2'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 155061-60-2
• Molecular Formula: C16H16O3
• Molecular Weight: 256.301
• Hs Code.: 2922299090
• Mol file: 155061-60-2.mol

Synonyms:2'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID ETHYL ESTER;Ethyl 2'-methoxy-biphenyl-4-carboxylate

Chemical Property of 2'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• PSA: 35.53000
• LogP: 3.53890

Purity/Quality:

2'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID ETHYL ESTER

There total 14 articles about 2'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-iodobenzoic acid ethyl ester (51934-41-9) + (2-methoxyphenyl)zinc chloride → 2'-methoxy-biphenyl-4-carboxylic acid ethyl ester (155061-60-2)

Guidance literature:

With tetrabutylammomium bromide; palladium diacetate; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol8007342

Reference yield: 98.0%

4-iodobenzoic acid ethyl ester (51934-41-9) + 2-Methoxyphenylboronic acid (5720-06-9) → 2'-methoxy-biphenyl-4-carboxylic acid ethyl ester (155061-60-2)

Guidance literature:

With potassium carbonate; In ethanol; water; at 20 ℃; for 2h; Sealed tube; Green chemistry;

DOI:10.1002/cssc.201402858

Reference yield: 89.9%

2-methoxy boronic acid + Ethyl 4-bromobenzoate (5798-75-4) → 2'-methoxy-biphenyl-4-carboxylic acid ethyl ester (155061-60-2)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In ethanol; hexane; dichloromethane; water; toluene;

upstream raw materials:

2-bromoanisole

4-iodobenzoic acid ethyl ester

4-iodoanisol

Ethyl 4-bromobenzoate

Downstream raw materials:

4-(2-methoxyphenyl)benzoic acid

Refernces

• 1、 Akram, Manjur O.,Shinde, Popat S.,Chintawar, Chetan C.,Patil, Nitin T.. "Gold(i)-catalyzed cross-coupling reactions of aryldiazonium salts with organostannanes". . p. 2865 - 2869. Retrieved 2018/05/03.
• 2、 -. "Method of manufacturing hydroxybiphenyls". Paragraph 0083-0084. . Retrieved 2020/11/19.