(2S,4R,5S)-(-)-2,5-DIPHENYL-3,4-DIMETHYL-1,3,2-OXAZAPHOSPHOLIDINE-2-BORANE

Base Information

• Chemical Name: (2S,4R,5S)-(-)-2,5-DIPHENYL-3,4-DIMETHYL-1,3,2-OXAZAPHOSPHOLIDINE-2-BORANE
• CAS No.: 223758-04-1
• Molecular Formula: C₃₈H₂₆O₂P₂
• Molecular Weight: 576.571
• Mol file: 223758-04-1.mol

Synonyms:(S)-(-)-2-[2-(DIPHENYLPHOSPHINO)PHENYL]-1,2,3-DINAPHTHO(D12,F12)DIOXAPHOSPHINE;(2S,4R,5S)-(-)-2,5-DIPHENYL-3,4-DIMETHYL-1,3,2-OXAZAPHOSPHOLIDINE-2-BORANE

Chemical Property of (2S,4R,5S)-(-)-2,5-DIPHENYL-3,4-DIMETHYL-1,3,2-OXAZAPHOSPHOLIDINE-2-BORANE

Chemical Property:

• PSA: 26.06000
• LogP: 2.46960

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S,4R,5S)-(-)-2,5-DIPHENYL-3,4-DIMETHYL-1,3,2-OXAZAPHOSPHOLIDINE-2-BORANE

There total 5 articles about (2S,4R,5S)-(-)-2,5-DIPHENYL-3,4-DIMETHYL-1,3,2-OXAZAPHOSPHOLIDINE-2-BORANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

<2-(diphenylphosphino)phenyl>phosphonous acid dichloride (223742-01-6) + 1,1'-bi-2-naphthol (602-09-5) → (R)-2-<2-(diphenylphosphino)phenyl>-1,3,2-dinaphtho1,2,f1,2>dioxaphosphepine (223758-04-1,245430-28-8)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/S0957-4166(98)00493-5

Reference yield: 80.0%

N,N,N',N'-tetraethyl-<2-(diphenylphosphino)phenyl>phosphonous acid diamide (245125-71-7) + 1,1'-bi-2-naphthol (602-09-5) → (R)-2-<2-(diphenylphosphino)phenyl>-1,3,2-dinaphtho1,2,f1,2>dioxaphosphepine (223758-04-1,245430-28-8)

Guidance literature:

In toluene; Heating;

DOI:10.1016/S0957-4166(99)00215-3

Reference yield:

(2-bromophenyl)diphenylphosphane (62336-24-7) → (R)-2-<2-(diphenylphosphino)phenyl>-1,3,2-dinaphtho1,2,f1,2>dioxaphosphepine (223758-04-1,245430-28-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, from -78 deg C to RT

2: 80 percent / toluene / Heating

With n-butyllithium; In toluene;

DOI:10.1016/S0957-4166(99)00215-3

upstream raw materials:

<2-(diphenylphosphino)phenyl>phosphonous acid dichloride

1,1'-bi-2-naphthol

N,N,N',N'-tetraethyl-<2-(diphenylphosphino)phenyl>phosphonous acid diamide

chloro-diphenylphosphine