(cis)2-iodocyclopropanecarboxylic acid

Base Information

• Chemical Name: (cis)2-iodocyclopropanecarboxylic acid
• CAS No.: 122676-92-0
• Molecular Formula: C4H5IO2
• Molecular Weight: 211.98577
• Hs Code.: 2902900000
• Mol file: 122676-92-0.mol

Synonyms:(cis)2-iodocyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 2-iodo-, (1R,2R)-rel-

Chemical Property of (cis)2-iodocyclopropanecarboxylic acid

Chemical Property:

• Melting Point: 74 °C
• Boiling Point: 293.9±33.0 °C(Predicted)
• PKA: 4.20±0.20(Predicted)
• PSA: 37.30000
• Density: 2.30±0.1 g/cm3(Predicted)
• LogP: 0.89450
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99.5% ^*data from raw suppliers

cis-2-Iodocyclopropanecarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (cis)2-iodocyclopropanecarboxylic acid

There total 3 articles about (cis)2-iodocyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(±)-(cis)-2-iodocyclopropyl-N,N-diethylcarboxamide (467426-68-2) → (±)-(cis)-2-iodocyclopropanecarboxylic acid (122676-92-0,692288-05-4,1932315-23-5)

Guidance literature:

With sulfuric acid; In acetic acid; for 240h; Reflux;

DOI:10.1021/acs.joc.7b00945

Reference yield: 78.0%

cis-1-(Hydroxymethyl)-2-iodocyclopropane (122676-95-3) → (±)-(cis)-2-iodocyclopropanecarboxylic acid (122676-92-0,692288-05-4,1932315-23-5)

Guidance literature:

With dipyridinium dichromate; In N,N-dimethyl-formamide; at 25 ℃; for 24h;

DOI:10.1021/ja00199a036

Reference yield:

4,5-Methano-1-hydroxyiodoxol-3(1H)-one (122676-91-9) → (±)-(cis)-2-iodocyclopropanecarboxylic acid (122676-92-0,692288-05-4,1932315-23-5) + 2-Iodoxycyclopropanecarboxylic acid (122676-94-2)

Guidance literature:

In methanol; for 24h; Ambient temperature;

DOI:10.1021/ja00199a036

upstream raw materials:

cis-1-(Hydroxymethyl)-2-iodocyclopropane

4,5-Methano-1-hydroxyiodoxol-3(1H)-one

(±)-(cis)-2-iodocyclopropyl-N,N-diethylcarboxamide

Downstream raw materials:

(1R,2R)-2-iodocyclopropanecarboxylic acid

(1S,2S)-2-iodocyclopropanecarboxylic acid

Refernces

• 1、 Cai, Shaopei,Dimitroff, Martin,McKennon, Tracey,Reider, Malcolm,Robarge, Lonnie,Ryckman, David,Shang, Xiao,Therrien, Joseph. "Process development on an efficient new convergent formal synthesis of MIV-150". . p. 353 - 359. Retrieved 2013/09/05.