1H-Pyrrole-2-carboxylic acid, 4-[3-(diMethylaMino)-2-Methyl-1-oxo-2-propen-1-yl]-1-[(4-Methylphenyl)sulfonyl]-, Methyl ester

Base Information

• Chemical Name: 1H-Pyrrole-2-carboxylic acid, 4-[3-(diMethylaMino)-2-Methyl-1-oxo-2-propen-1-yl]-1-[(4-Methylphenyl)sulfonyl]-, Methyl ester
• CAS No.: 1191272-70-4
• Molecular Formula: C19H22N2O5S
• Molecular Weight: 390.45338
• Mol file: 1191272-70-4.mol

Synonyms:1H-Pyrrole-2-carboxylic acid, 4-[3-(diMethylaMino)-2-Methyl-1-oxo-2-propen-1-yl]-1-[(4-Methylphenyl)sulfonyl]-, Methyl ester;(E)-methyl 4-(3-(dimethylamino)-2-methylacryloyl)-1-tosyl-1H-pyrrole-2-carboxylate

Chemical Property of 1H-Pyrrole-2-carboxylic acid, 4-[3-(diMethylaMino)-2-Methyl-1-oxo-2-propen-1-yl]-1-[(4-Methylphenyl)sulfonyl]-, Methyl ester

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

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Technology Process of 1H-Pyrrole-2-carboxylic acid, 4-[3-(diMethylaMino)-2-Methyl-1-oxo-2-propen-1-yl]-1-[(4-Methylphenyl)sulfonyl]-, Methyl ester

There total 2 articles about 1H-Pyrrole-2-carboxylic acid, 4-[3-(diMethylaMino)-2-Methyl-1-oxo-2-propen-1-yl]-1-[(4-Methylphenyl)sulfonyl]-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.5%

dimethylformamide di-tert-butylacetal + methyl 4-propionyl-1-tosyl-1H-pyrrole-2-carboxylate (1191272-69-1) → methyl 4-(3-(dimethylamino)-2-methylacryloyl)-1-tosyl-1H-pyrrole-2-carboxylate (1191272-70-4)

Guidance literature:

In toluene; at 75 ℃; for 24h;

DOI:10.1021/jm900630q

Reference yield:

methyl 4-propionyl-1-tosyl-1H-pyrrole-2-carboxylate (1191272-69-1) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → methyl 4-(3-(dimethylamino)-2-methylacryloyl)-1-tosyl-1H-pyrrole-2-carboxylate (1191272-70-4)

Guidance literature:

In N,N-dimethyl-formamide; at 70 ℃; for 18h;

Reference yield: 90.0%

methyl 4-(3-(dimethylamino)-2-methylacryloyl)-1-tosyl-1H-pyrrole-2-carboxylate (1191272-70-4) + 2,3-dimethylphenylguanidine hydrochloride → 4-(2-(2,3-dimethylphenylamino)-5-methylpyrimidin-4-yl)-1-tosyl-1H-pyrrole-2-carboxylic acid (1217184-50-3)

Guidance literature:

methyl 4-(3-(dimethylamino)-2-methylacryloyl)-1-tosyl-1H-pyrrole-2-carboxylate; 2,3-dimethylphenylguanidine hydrochloride; With N-ethyl-N,N-diisopropylamine; In toluene; for 20h; Reflux;

With water; lithium hydroxide; In tetrahydrofuran; Reflux;

DOI:10.1021/jm900630q

upstream raw materials:

methyl 4-propionyl-1-tosyl-1H-pyrrole-2-carboxylate

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

4-(2-(2,3-dimethylphenylamino)-5-methylpyrimidin-4-yl)-1-tosyl-1H-pyrrole-2-carboxylic acid

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