Hydroxy Ritonavir

Base Information

• Chemical Name: Hydroxy Ritonavir
• CAS No.: 176655-56-4
• Molecular Formula: C₃₇H₄₈N₆O₆S₂
• Molecular Weight: 736.957
• Mol file: 176655-56-4.mol

Synonyms:Hydroxy Ritonavir;[5S-(5R*,8R*,10R*,11R*)]-10-Hydroxy-1-[2-(1-hydroxy-1-Methylethyl)-4-thiazolyl]-2-Methyl-5-(1-Methylethyl)-3,6-dioxo-8,11-bis(phenylMethyl)-;Ritonavir IMpurity E (Hydroxy Ritonavir)

Chemical Property of Hydroxy Ritonavir

Chemical Property:

• PSA: 232.96000
• LogP: 6.25830
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

Hydroxy ritonavir ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Ritonavir (R535000), HIV-1 protease inhibitor. Hydroxy Ritonavir (Ritonavir EP Impurity E) is a metabolite of Ritonavir (R535000), HIV-1 protease inhibitor. It is a COVID19-related research product.

Technology Process of Hydroxy Ritonavir

There total 2 articles about Hydroxy Ritonavir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ritonavir (155213-67-5) → N-ritonavir (176655-55-3) + C30H39N5O5S (176655-57-5) + hydroxy ritonavir (176655-56-4) + C36H46N6O5S2

Guidance literature:

With human CYP₃A₄; NADPH; NADPH-cytochrome P₄₅₀ reductase; In aq. phosphate buffer; at 37 ℃; for 0.333333h; pH=7.7; Enzymatic reaction;

DOI:10.1124/dmd.113.053108

Reference yield:

ritonavir (155213-67-5) → N-ritonavir (176655-55-3) + hydroxy ritonavir (176655-56-4)

Guidance literature:

With human CYP₂B₆; NADPH; NADPH-cytochrome P₄₅₀ reductase; In aq. phosphate buffer; at 37 ℃; for 0.333333h; pH=7.7; Enzymatic reaction;

DOI:10.1124/dmd.113.053108

upstream raw materials:

ritonavir