8-Methyl-1,3,8-triazaspiro[4.5]decane-2,4-dione

Base Information

• Chemical Name: 8-Methyl-1,3,8-triazaspiro[4.5]decane-2,4-dione
• CAS No.: 52094-69-6
• Molecular Formula: C8H13 N3 O2
• Molecular Weight: 183.21
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID80200081
• ChEMBL ID: CHEMBL1507546
• Mol file: 52094-69-6.mol

Synonyms:8-methyl-1,3,8-triazaspiro[4.5]decane-2,4-dione;52094-69-6;BRN 0168499;1,3,8-Triazaspiro(4.5)decane-2,4-dione, 8-methyl-;8-Methyl-1,3,8-triazaspiro(4.5)decane-2,4-dione;4-26-00-00564 (Beilstein Handbook Reference);MLS000056238;SCHEMBL1630966;CHEMBL1507546;DTXSID80200081;ZGSNEAYELPMHGT-UHFFFAOYSA-N;HMS2324J03;AB7644;MFCD01679435;AKOS001077119;1-Methylpiperidine-4-spiro-5'-hydantoin;SMR000067905;1 -methylpiperidine-4-spiro-5'-hydantoin;LS-154735;EU-0029972;FT-0729069;EN300-12202;A918439;J-519455;8-methyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione;Z85917567;F0918-7116

Chemical Property of 8-Methyl-1,3,8-triazaspiro[4.5]decane-2,4-dione

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 68.42000
• Density: g/cm³
• LogP: -0.85600
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 183.100776666
• Heavy Atom Count: 13
• Complexity: 256

Purity/Quality:

97% ^*data from raw suppliers

8-Methyl-1,3,8-triazaspiro[4.5]decane-2,4-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC2(CC1)C(=O)NC(=O)N2

Technology Process of 8-Methyl-1,3,8-triazaspiro[4.5]decane-2,4-dione

There total 6 articles about 8-Methyl-1,3,8-triazaspiro[4.5]decane-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-Methyl-4-piperidone (1445-73-4) + potassium cyanide + ammonium carbonate (506-87-6,6721-33-1,10361-29-2) → 8-methyl-1,3,8-triazaspiro<4.5>decane-2,4-dione (52094-69-6)

Guidance literature:

In methanol; water; at 90 ℃; for 0.166667h; Sealed tube; Microwave irradiation;

DOI:10.1016/j.tetlet.2016.05.065

Reference yield: 45.0%

1-Methyl-4-piperidone (1445-73-4) + potassium cyanide (151-50-8) + ammonium carbonate (506-87-6,6721-33-1,10361-29-2) → 8-methyl-1,3,8-triazaspiro<4.5>decane-2,4-dione (52094-69-6)

Guidance literature:

In ethanol; at 60 ℃; for 48h;

Reference yield: 35.0%

1-Methyl-4-piperidone (1445-73-4) + potassium cyanide → 8-methyl-1,3,8-triazaspiro<4.5>decane-2,4-dione (52094-69-6)

Guidance literature:

With ammonium carbonate; In methanol; water; at 140 ℃; for 0.133333h; Sealed vial; Microwave irradiation;

DOI:10.3998/ark.5550190.0012.221

upstream raw materials:

1-Methyl-4-piperidone

potassium cyanide

ammonium carbonate

ethyl 1-methyl-4-oxo-piperidin-3-carboxylate

Downstream raw materials:

3-[(Dibenzhydrylamino)-methyl]-8-methyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione

4-amino-1-methyl-4-piperidinecarboxylic acid