3-AMino-1-Boc-4,4-difluoropyrrolidine

Base Information

• Chemical Name: 3-AMino-1-Boc-4,4-difluoropyrrolidine
• CAS No.: 1408074-83-8
• Molecular Formula: C9H16F2N2O2
• Molecular Weight: 222.235
• Hs Code.: 2933998090
• Mol file: 1408074-83-8.mol

Synonyms:3-AMino-1-Boc-4,4-difluoropyrrolidine;tert-butyl 4-amino-3,3-difluoropyrrolidine-1-carboxylate

Chemical Property of 3-AMino-1-Boc-4,4-difluoropyrrolidine

Chemical Property:

• Boiling Point: 261.7±40.0 °C(Predicted)
• PKA: 7.03±0.40(Predicted)
• Density: 1.20±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

95% ^*data from raw suppliers

tert-Butyl4-Amino-3,3-difluoropyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Tert-Butyl 4-Amino-3,3-Difluoropyrrolidine-1-Carboxylate is a useful research chemical.

Technology Process of 3-AMino-1-Boc-4,4-difluoropyrrolidine

There total 5 articles about 3-AMino-1-Boc-4,4-difluoropyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 3,3-difluoro-4-{[(trifluoromethyl)sulfonyl]oxy}pyrrolidine-1-carboxylate → tert-butyl 4-amino-3,3-difluoropyrrolidine-1-carboxylate (1408074-83-8)

Guidance literature:

With tetrabutylammoniun azide; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere; Cooling with ice;

Reference yield:

tert-butyl 4-azido-3,3-difluoropyrrolidine-1-carboxylate (1610703-68-8) → tert-butyl 4-amino-3,3-difluoropyrrolidine-1-carboxylate (1408074-83-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 15h; Inert atmosphere;

Reference yield:

tert-butyl 3-azido-4-oxopyrrolidine-1-carboxylate (1648727-30-3) → tert-butyl 4-amino-3,3-difluoropyrrolidine-1-carboxylate (1408074-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 36 h / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 15 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In methanol; dichloromethane;

upstream raw materials:

tert-butyl 3-azido-4-oxopyrrolidine-1-carboxylate

(±)-tert-butyl 3-azido-4-hydroxypyrrolidine-1-carboxylate

tert-butyl 4-azido-3,3-difluoropyrrolidine-1-carboxylate

tert-butyl 3,3-difluoro-4-hydroxy-pyrrolidine-1-carboxylate

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