Benzoic acid, 4-[(1R)-1-[(R)-(4-chlorophenyl)hydroxyMethyl]butyl]-, 1,1-diMethylethyl ester

Base Information

• Chemical Name: Benzoic acid, 4-[(1R)-1-[(R)-(4-chlorophenyl)hydroxyMethyl]butyl]-, 1,1-diMethylethyl ester
• CAS No.: 1215767-71-7
• Molecular Formula: C22H27ClO3
• Molecular Weight: 374.908
• Mol file: 1215767-71-7.mol

Synonyms:Benzoic acid, 4-[(1R)-1-[(R)-(4-chlorophenyl)hydroxyMethyl]butyl]-, 1,1-diMethylethyl ester;tert-butyl4-((1R,2R)-1-(4-chlorophenyl)-1-hydroxypentan-2-yl)benzoate

Chemical Property of Benzoic acid, 4-[(1R)-1-[(R)-(4-chlorophenyl)hydroxyMethyl]butyl]-, 1,1-diMethylethyl ester

Chemical Property:

• PSA: 46.53000
• LogP: 5.91260
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl4-((1R,2R)-1-(4-chlorophenyl)-1-hydroxypentan-2-yl)benzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-[(1R)-1-[(R)-(4-chlorophenyl)hydroxyMethyl]butyl]-, 1,1-diMethylethyl ester

There total 3 articles about Benzoic acid, 4-[(1R)-1-[(R)-(4-chlorophenyl)hydroxyMethyl]butyl]-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.1%

tert-butyl 4-[1-(4-chlorobenzoyl)butyl]benzoate (1019113-44-0) → tert-butyl 4-{1-[(4-chlorophenyl)(hydroxyl)methyl]butyl}benzoate (1019113-45-1) + tert-butyl 4-{(1R)-1-[(R)-(4-chlorophenyl)(hydroxyl)methyl]butyl}benzoate (1215767-71-7)

Guidance literature:

With RuCl₂[(S)-(DM-SEGPHOS)][(S)-DAIPEN]; potassium tert-butylate; hydrogen; In isopropyl alcohol; at 20 - 25 ℃; for 4h; under 4913.04 - 5171.62 Torr; Inert atmosphere;

DOI:10.1021/op300249q

Reference yield:

tert-butyl 4-[1-(4-chlorobenzoyl)butyl]benzoate (1019113-44-0) → tert-butyl 4-{(1R)-1-[(R)-(4-chlorophenyl)(hydroxyl)methyl]butyl}benzoate (1215767-71-7)

Guidance literature:

With potassium tert-butylate; hydrogen; RuCl₂[(S)-xyl-SEGPHOS][(S)-DAIPEN]; In isopropyl alcohol; at 20 ℃; for 18h;

Reference yield:

tert-butyl 4-[1-(4-chlorobenzoyl)butyl]benzoate (1019113-44-0) → tert-butyl 4-{(1R)-1-[(R)-(4-chlorophenyl)(hydroxyl)methyl]butyl}benzoate (1215767-71-7) + C22H27ClO3 + C22H27ClO3 + C22H27ClO3

Guidance literature:

With potassium tert-butylate; hydrogen; dichloro[(S)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole][(S)-1,1-bis(4-methoxyphenyl)-3-methylbutane-1,2-diamine]ruthenium(II); In isopropyl alcohol; at 20 ℃; for 18h; under 5171.62 Torr;

upstream raw materials:

tert-butyl 4-[1-(4-chlorobenzoyl)butyl]benzoate

Downstream raw materials:

(R)-4-[2-(4-chlorophenyl)-1-propylethan-2-one-1-yl]benzoic acid tert-butyl ester

tert-butyl 4-[(1R)-1-((R)-(4-chlorophenyl){[4-(trifluoromethoxy)benzyl]oxy}methyl)butyl]benzoate

tert-butyl 4-{(1R)-1-[(R)-[(2-trifluoromethylquinolin-4-yl)oxy](4-chlorophenyl)methyl]butyl}benzoate

tert-butyl 4-{(1R)-1-[(S)-bromo(4-chlorophenyl)methyl]butyl}benzoate

Refernces

• 1、 -. "GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE". Page/Page column 39. . Retrieved 2010/04/06.
• 2、 -. "GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE". Page/Page column 35. . Retrieved 2010/08/09.