2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Base Information

Chemical Name:2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine
CAS No.:647863-02-3
Molecular Formula:C8H8F3N3
Molecular Weight:239.628
Hs Code.:2933990090
DSSTox Substance ID:DTXSID90594029
Wikidata:Q82488725
Mol file:647863-02-3.mol

Synonyms:2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine;647863-02-3;737754-25-5;2-Trifluoromethyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine;SCHEMBL1620576;DTXSID90594029;AKOS016013484;AB53033;AM807405;DB-347342;DB-349712;CS-0092012;J-506660;5,6,7,8-TETRAHYDRO-2-(TRIFLUOROMETHYL)-PYRIDO[3,4-D]PYRIMIDINE

Suppliers and Price of 2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine 95+%
1g
$ 614.00

American Custom Chemicals Corporation
2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE 95.00%
5MG
$ 500.76

Alichem
2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine
1g
$ 530.00

Total 11 raw suppliers

Chemical Property of 2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Chemical Property:

PSA：37.81000
LogP:1.46990
Storage Temp.:2-8°C
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:0
Exact Mass:203.06703175
Heavy Atom Count:14
Complexity:207

Purity/Quality:

98%min ^*data from raw suppliers

2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCC2=NC(=NC=C21)C(F)(F)F

Technology Process of 2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

There total 1 articles about 2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 647863-01-2
4-chloro-7-(phenylmethyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

: 647863-02-3
2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; for 7.5h; under 760.051 Torr;

Reference yield: 86.0%

: 611240-55-2
C₂₂H₂₆FNO₅

: 647863-02-3
2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

: 7-[(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2-benzyloxy-5-fluorophenyl)butanoyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane;

Reference yield:

: 647863-02-3
2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

: 486460-00-8,922178-94-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

: 7-[(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In acetonitrile; at 5 ℃; for 2h;