3-Chloropyrazine-2,6-diamine

Base Information

• Chemical Name: 3-Chloropyrazine-2,6-diamine
• CAS No.: 794497-98-6
• Molecular Formula: C4H5ClN4
• Molecular Weight: 144.5623
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID10477587
• Wikidata: Q82310377
• Mol file: 794497-98-6.mol

Synonyms:3-chloropyrazine-2,6-diamine;794497-98-6;3-CHLORO-PYRAZINE-2,6-DIAMINE;2,6-Diamino-3-chloropyrazine;SCHEMBL2414672;DTXSID10477587;KSEHSAXZBNRCCY-UHFFFAOYSA-N;MFCD15144345;AKOS006338335;SB38806;AS-43712;CS-0341082;A1-00483

Chemical Property of 3-Chloropyrazine-2,6-diamine

Chemical Property:

• PSA: 77.82000
• LogP: 1.45680
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 144.0202739
• Heavy Atom Count: 9
• Complexity: 98.6

Purity/Quality:

97% ^*data from raw suppliers

3-Chloro-pyrazine-2,6-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N=C(C(=N1)Cl)N)N

Technology Process of 3-Chloropyrazine-2,6-diamine

There total 3 articles about 3-Chloropyrazine-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3,5-diamino-6-chloro-pyrazine-2-carboxylic acid methyl ester (1458-01-1) → 3-chloro-2,6-pyrazinediamine (794497-98-6)

Guidance literature:

3,5-diamino-6-chloro-pyrazine-2-carboxylic acid methyl ester; With lithium hydroxide; water; In methanol; at 90 ℃; for 1.5h;

With hydrogenchloride; In 1,4-dioxane; water; at 100 ℃; for 2h;

With sodium carbonate; In water; pH=8;

Reference yield: 18.0%

amiloride hydrochloride → N-[(3,5-diamino-6-chloro-2-pyrazinyl)carbonyl]urea (23656-84-0) + 3-chloro-2,6-pyrazinediamine (794497-98-6) + amiloride acetate

Guidance literature:

In acetate buffer; for 24h; pH=4.6; Heating;

DOI:10.3797/scipharm.aut-04-10

Reference yield:

3,5-diamino-6-chloropyrazine-2-carboxylic acid lithium salt (1080018-69-4) → 3-chloro-2,6-pyrazinediamine (794497-98-6)

Guidance literature:

3,5-diamino-6-chloropyrazine-2-carboxylic acid lithium salt; With hydrogenchloride; In 1,4-dioxane; water; at 100 ℃; for 2h;

With sodium carbonate; In water; pH=8;

upstream raw materials:

3,5-diamino-6-chloropyrazine-2-carboxylic acid lithium salt

3,5-diamino-6-chloro-pyrazine-2-carboxylic acid methyl ester

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