(-)-(1R,3S)-3-AMINOCYCLOPENTANECARBOXYLIC ACID

Base Information

• Chemical Name: (-)-(1R,3S)-3-AMINOCYCLOPENTANECARBOXYLIC ACID
• CAS No.: 19042-34-3
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.159
• Mol file: 19042-34-3.mol

Synonyms:(-)-(1R,3S)-BETA-HOMOCYCLOLEUCINE;(1R,3S)-3-(amino)cyclopentane-1-carboxylic acid

Chemical Property of (-)-(1R,3S)-3-AMINOCYCLOPENTANECARBOXYLIC ACID

Chemical Property:

• Melting Point: 172.1 °C
• PSA: 63.32000
• LogP: 0.89870

Purity/Quality:

99.90% ^*data from raw suppliers

(1R,3S)-3-Aminocyclopentane-1-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26-22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (-)-(1R,3S)-3-AMINOCYCLOPENTANECARBOXYLIC ACID

There total 16 articles about (-)-(1R,3S)-3-AMINOCYCLOPENTANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

trans-4-aminocyclopent-2-ene-1-carboxylic acid → trans-3-aminocyclopentane-1-carboxylic acid (19042-34-3,19297-28-0,49805-32-5,57376-72-4,71376-02-8,71830-07-4,71830-08-5,71869-43-7,89614-96-0)

Guidance literature:

With hydrogen; 10% palladium on active carbon; In acetic acid; Ambient temperature;

DOI:10.1071/CH9860855

Reference yield: 78.0%

trans-3-phthalimidocyclopentane-1-carboxylic acid → trans-3-aminocyclopentane-1-carboxylic acid (19042-34-3,19297-28-0,49805-32-5,57376-72-4,71376-02-8,71830-07-4,71830-08-5,71869-43-7,89614-96-0)

Guidance literature:

With hydrazine; In methanol; Heating;

DOI:10.1071/CH9860855

Reference yield:

3-tosyl-2-azabicyclo [2.2.1]hepta-2,5-diene (49805-27-8) → trans-3-aminocyclopentane-1-carboxylic acid (19042-34-3,19297-28-0,49805-32-5,57376-72-4,71376-02-8,71830-07-4,71830-08-5,71869-43-7,89614-96-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) glacial acetic acid, 2.)HCl 4M / 1.) 15 min, 2.) 16 h,room temperature

2: 0.5 h / 200 °C

3: H₂NNH₂ / methanol / 0.5 h / Heating

4: 90 percent / hydrogen / 10percentPd-C / acetic acid / Ambient temperature

With hydrogenchloride; hydrogen; acetic acid; hydrazine; 10% palladium on active carbon; In methanol; acetic acid;

DOI:10.1071/CH9860855

upstream raw materials:

methyl 3-aminocyclopentane-1-carboxylate

3-tosyl-2-azabicyclo [2.2.1]hepta-2,5-diene

cis-4-amino-cyclopent-2-ene-1-carboxylic acid

cyclopent-1-enecarbonitrile