8-Oxo-Benzylguanine

Base Information

• Chemical Name: 8-Oxo-Benzylguanine
• CAS No.: 158754-46-2
• Molecular Formula: C₁₂H₁₁N₅O₂
• Molecular Weight: 257.252
• Mol file: 158754-46-2.mol

Synonyms:8-Oxo-Benzylguanine

Chemical Property of 8-Oxo-Benzylguanine

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

8-Oxo-Benzylguanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 8-Oxo-Benzylguanine is a derivative of O-Benzylguanine, an reversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. O-Benzylguanine is known to assists in the protection against carcinogenic and therapeutic alkylating agents.

Technology Process of 8-Oxo-Benzylguanine

There total 2 articles about 8-Oxo-Benzylguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-6-(benzyloxy)-5-((4-chlorophenyl)diazenyl)pyrimidine-2,4-diamine → 8-Oxo-benzylguanine (158754-46-2)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc; acetic acid / ethanol / 2 h / 70 °C / Inert atmosphere

2: toluene; dichloromethane / 2 h / 20 °C / Inert atmosphere

With acetic acid; zinc; In ethanol; dichloromethane; toluene;

DOI:10.1039/c7md00268h

Reference yield:

O6-benzylguanine → 8-Oxo-benzylguanine (158754-46-2)

Guidance literature:

With aldehyde oxidase-1; cytochrome P₄₅₀;

DOI:10.1124/dmd.118.082099

Refernces

• 1、 Xie, Jiarong,Saburulla, Nur Fazilah,Chen, Shiyan,Wong, Siew Ying,Yap, Ze Ping,Zhang, Linghua Harris,Lau, Aik Jiang. "Evaluation of carbazeran 4-oxidation and O6-benzylguanine 8-oxidation as catalytic markers of human aldehyde oxidase: Impact of cytosolic contamination of liver microsomes". . p. 26 - 37. Retrieved 2019.